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Structural Mechanism for Cargo Recognition by the Retromer Complex
Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to the trans-Golgi network and the plasma membrane. Defects in retromer impair various cellular processes andExpand
A Recycling-Defective Vacuolar Sorting Receptor Reveals an Intermediate Compartment Situated between Prevacuoles and Vacuoles in Tobacco[W]
This work examines two mutations of the same motif in a vacuolar sorting receptor that have opposite effects on the protein’s localization, shedding light on the full transport cycle of the receptor.Expand
Evidence for Sequential Action of Rab5 and Rab7 GTPases in Prevacuolar Organelle Partitioning
GTPases of the Rab5 and Rab7 families were shown to control vacuolar sorting but their specific subcellular localization is controversial in plants. Here, we show that both the canonical as well asExpand
Mechanisms and Concepts Paving the Way towards a Complete Transport Cycle of Plant Vacuolar Sorting Receptors[W][OA]
Delivery of proteins to the lytic vacuole in plants is a complex cascade of selective interactions that specifically excludes residents of the endoplasmic reticulum and secreted proteins. VacuolarExpand
Novel role for the midbody in primary ciliogenesis by polarized epithelial cells
Polarized epithelial cells assemble a primary cilium by an unknown mechanism. After cytokinesis, the central part of the intercellular bridge, which is referred to as the midbody, is inherited as aExpand
TSSC1 is novel component of the endosomal retrieval machinery
A previously uncharacterized WD40 domain–containing protein named TSSC1 is shown to interact with the GARP and EARP tethering complexes, promoting retrograde transport of Shiga toxin from endosomesExpand
Golgi-Dependent Transport of Vacuolar Sorting Receptors Is Regulated by COPII, AP1, and AP4 Protein Complexes in Tobacco[W][OPEN]
Receptor-mediated protein sorting to plant vacuoles is a step-wise process, as the receptor has to be targeted to the correct cell compartment, release its cargo, and recycle to start a new proteinExpand
A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes
Golgi-associated retrograde protein (GARP) and endosome-associated recycling protein (EARP) are related heterotetrameric complexes that associate with the cytosolic face of the trans-Golgi networkExpand
The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
SUMMARY Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, aExpand
Direct trafficking pathways from the Golgi apparatus to the plasma membrane
Abstract In eukaryotic cells, protein sorting is a highly regulated mechanism important for many physiological events. After synthesis in the endoplasmic reticulum and trafficking to the GolgiExpand