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A number of multi-hop, wireless, network programming systems have emerged for sensor network retasking but none of these systems support a cryptographically-strong, public-key-based system for source authentication and integrity verification. The traditional technique for authenticating a program binary, namely a digital signature of the program hash, is(More)
[3H]GABA quantitative autoradiography was used to examine the binding kinetics and regional distribution of GABAB receptors in rat brain. The regional distribution was compared to that of GABAA receptors. At 4 degrees C, [3H]GABA binding to GABAB receptors reached equilibrium within 45 min. The association and dissociation rate constants for GABAB binding(More)
GABAB and GABAA binding sites were evaluated by quantitative autoradiography of 3H-GABA binding in superior frontal gyrus of persons who died with dementia of the Alzheimer's type (DAT) and of age-matched normal controls. Scatchard analysis and competition studies disclosed 48 to 68% and 25% decrements in receptor density (Bmax) for GABAB and GABAA(More)
Tritiated N-(1-[2-thienylcyclohexyl)-3,4-piperi-dine ([3H]TCP), a derivative of the dissociative anesthetic phencyclidine (PCP), has recently been shown to bind specifically to a o-opiate receptor within the central nervous system of the rat (Sircar and Zukin, 1985). Drugs of this class noncompeti-tively inhibit the excitatory properties of(More)
We have previously demonstrated a marked loss in N-methyl-D-aspartate (NMDA) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the Alzheimer type (DAT). In addition, we have found that the dissociative anesthetic N-(1-[2-thienyl]cyclohexyl)3,4-piperidine ([3H]TCP) binds to a site whose regional distribution is highly(More)
INTRODUCTION Available assays for quantitation of the Alzheimer's disease (AD) biomarker amyloid-beta 1-42 (Aβ [1-42]) in cerebrospinal fluid demonstrate significant variability and lack of standardization to reference measurement procedures (RMPs). We report analytical performance data for the novel Elecsys β-amyloid (1-42) assay (Roche Diagnostics). (More)
  • Prabal Kumar, Dutta Jonathan, W Hui, David Chiyuan, Chu David, E Culler +4 others
  • 2005
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The neuronal localization of glutamate and phencyclidine (PCP) receptors was evaluated in the cerebral cortex and hippocampal formation of rat CNS using quantitative autoradiography. Scatchard analysis of [3H]glutamate binding in the cortex (layers I and II and V and VI) showed no difference in the total number of binding sites (Bmax) or apparent affinity(More)
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