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Journals and Conferences
Growth factors are signal proteins that regulate the cellular processes in wound healing. By manipulating the actions of growth factors, it may be possible to accelerate or modify wound healing. Currently, intense research is being conducted throughout the world to investigate this possibility. In otolaryngology, the impact of improved wound healing could… (More)
Thyroid hematoma is a rare cause of airway obstruction in victims of blunt trauma. The case of a 34-year-old woman who developed orthopnea after a low-energy motor vehicle accident is described. Presenting greater than 24 hours after her accident, the patient noted dysphagia, tracheal deviation, and postural dyspnea. The diagnosis of thyroid gland hematoma… (More)
PURPOSE Tympanic membrane perforations are very common and often require surgical treatment. Recent studies have suggested that growth factors may be an effective nonsurgical alternative for treating chronic perforations. The purpose of this study was to assess the efficacy of a platelet releasate in the treatment of chronic nonhealing perforations in the… (More)
OBJECTIVE To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers. METHODS A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs… (More)
Many advances in wound healing have relevance to facial plastic surgery. We briefly highlight some of these advances, including new biological and synthetic products and other potential technologies to improve wound healing, as well as the literature describing them.
An immense amount of knowledge has been gained over the last decade in the realm of polypeptide growth factors. Only recently has this new information made an impact in otolaryngology. This article is a brief overview of peptide growth factors in relation to wound healing and otolaryngology.
OBJECTIVES/HYPOTHESIS Persistent, poorly healing wounds are a significant clinical problem in patients who have had previous irradiation. Despite current treatments, refractory nonhealing soft tissue wounds persist. The study described one of the earliest reported uses of recombinant human platelet-derived growth factor-BB (rhPDGF) gel to improve the… (More)
Fifty-one patients were enrolled in a study and underwent primary rhinoplasty. Serial nasal tip projection measurements were made preoperatively, intraoperatively, and 6 months postoperatively. Actual changes in measured nasal tip projection were evaluated with respect to preoperative goals and specific procedures used to accomplish these goals in the nasal… (More)
Optimal wound healing and its close relationship to a patient's positive nutritional balance is well known. For years, physicians have attempted to improve the metabolic status of patients after surgery or trauma. Currently, major emphasis is placed on perioperative nutritional status and its effect on postoperative wound healing. The intricacies of… (More)
The healing of a surgical wound is significantly affected by radiation. Radiation can affect all cells within its treatment field, thus making irradiated tissue more susceptible to trauma, infection, and irritation. In the irradiated patient, careful preoperative planning and a preventive approach to optimize conditions for wound healing are crucial to… (More)