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- David Brea, M Victoria Blanco, +6 authors J. Vázquez Castillo
- Journal of cerebral blood flow and metabolism…
- 2011
Stroke triggers an intense inflammatory response that could be a consequence of Toll-like receptors (TLRs) activation. However, the clinical significance and the therapeutic possibilities of TLR in… (More)
- Corinne Benakis, David Brea, +9 authors Josef Anrather
- Nature Medicine
- 2016
Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear whether the microbiota has an impact on… (More)
- Isabel Lema, Tomás Sobrino, Juan Antonio Godino Durán, David Brea, ElÃo DÃez-Feijóo
- The British journal of ophthalmology
- 2009
BACKGROUND/AIMS
Tissue degradation in corneal thinning disorders, such as keratoconus (KC), involves the expression of inflammatory mediators. The purpose of this study was to determine the levels of… (More)
- Francisco Campos, Tomás Sobrino, +6 authors J. Vázquez Castillo
- Journal of cerebral blood flow and metabolism…
- 2011
As ischemic stroke is associated with an excessive release of glutamate into the neuronal extracellular space, a decrease in blood glutamate levels could provide a mechanism to remove it from the… (More)
OBJECTIVE
We aimed to study endothelial function with biochemical and ultrasonographic markers and its relation with endothelial progenitor cells (EPCs) in patients with migraine.
METHODS
We… (More)
- Manuel RodrÃguez-Yáñez, Tomás Sobrino, +6 authors J. Vázquez Castillo
- Disease markers
- 2009
BACKGROUND
Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to… (More)
- Tomás Sobrino, Olivia Hurtado, +10 authors J. Vázquez Castillo
- Stroke
- 2007
BACKGROUND AND PURPOSE
Increased circulating endothelial progenitor cells (EPC) have been associated with a low cardiovascular risk and may be involved in endothelial cell regeneration. The present… (More)
- David Brea, Tomás Sobrino, Pedro Ramos-Cabrer, J. Vázquez Castillo
- Cerebrovascular diseases
- 2009
Neuronal death produced by cerebral ischemia activates innate immunity by Toll-like receptors and triggers inflammatory response. This response is necessary to remove cell debris and to start… (More)
- David Brea, Tomás Sobrino, +6 authors J. Vázquez Castillo
- Clinical immunology
- 2011
Toll-like receptors are innate immunity receptors that activate inflammation and adaptive immunity. Our objectives were to analyze the association between TLR3, 7, 8 and 9 expressions and clinical… (More)
- Manuel RodrÃguez-Yáñez, Tomás Sobrino, +9 authors J. Vázquez Castillo
- Stroke
- 2011
BACKGROUND AND PURPOSE
Clinical-diffusion mismatch (CDM; National Institutes of Health Stroke Scale score≥8 and diffusion-weighted imaging lesion volume<25 mL) has been suggested as a surrogate of… (More)