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1 The role of nitric oxide (NO) derived from constitutive and inducible nitric oxide synthase (cNOS and iNOS) and its relationship to oxygen-derived free radicals and prostaglandins (PG) was… (More)
The conceptual segregation of G protein-stimulated cell signaling responses into those mediated by heterotrimeric G proteins versus those promoted by small GTPases of the Ras superfamily is no longer… (More)
The role of peroxynitrite generated from nitric oxide and superoxide anion was investigated in a model of acute inflammation induced by the injection of carrageenan into the rat hind paw. Paw edema… (More)
Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. We… (More)
Phospholipase C (PLC) catalyzes the hydrolysis of PtdIns(4,5)P2, which results in both formation of the second messengers Ins(1,4,5)P3 and diacylglycerol and alteration in the membrane association… (More)
This paper intends to present a methodology to maximise reuse of regenerative braking energy in automatic metro lines for both offline and real time energy management. It first describes optimisation… (More)
1. Serotonin (5-hydroxytryptamine, 5-HT) has been shown to increase cyclic AMP production in dispersed cell aggregates from the major salivary glands of the rat. The goal of the present study was to… (More)
Early detection of protein biomarkers is critical to the study of human disease (e.g. cancer, inflammation/autoimmunity, neurodegeneration). Basic research scientists as well as translational… (More)
e22264 Background: The aim of this study was to identify novel biomarkers that may be capable of guiding the management of screen-detected indeterminate pulmonary nodules in the setting of lung can...