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We examined the effects of chronic, subchronic and acute treatment with haloperidol on the ME, the MERGL and enkephalin precursor concentrations in rat brain. The changes affected primarily the striatum. The ME content was greatly increased by the treatment, the precursor level was decreased by the haloperidol treatment. The specific mRNA for proenkephalin… (More)
We screened family members of monozygotic twins with keratoconus to search for a corneal thinning disorder using clinical, videokeratographic, and pachymetric analyses. The parents had bilateral astigmatism of a symmetric bow-tie pattern with normal videokeratographic and pachymetric indices. The 8-year-old sister had slightly asymmetric astigmatism in both… (More)
In 2014, UN Member States proposed a set of Sustainable Development Goals (SDGs), which will succeed the Millennium Development Goals (MDGs) as reference goals for the international development community for the period 2015-2030. The proposed goals and targets can be seen as a network, in which links among goals exist through targets that refer to multiple… (More)
We review Quillen's concept of a model category as the proper setting for deening derived functors in non-abelian settings, explain how one can transport a model structure from one category to another by mean of adjoint functors (under suitable assumptions), and deene such structures for categories of cosimplicial coalgebras. 1. Introduction Model… (More)
Opioid binding sites have been characterized pharmacologically in membranes from different areas of the rat brain. Delta, mu and sites belonging to the kappa family (K1, K2, K3) have been detected. Delta sites were more abundant in cortex and striatum, mu sites in striatum and hypothalamus, while kappa binding site concentration was higher in deeper… (More)
We define a sequence of purely algebraic invariants – namely, classes in the Quillen cohomology of the Π-algebra π * X – for distinguishing between different homotopy types of spaces. Another sequence of such cohomology classes allows one to decide whether a given abstract Π-algebra can be realized as the homotopy Π-algebra of a space.
Given a diagram of …–algebras (graded groups equipped with an action of the primary homotopy operations), we ask whether it can be realized as the homotopy groups of a diagram of spaces. The answer given here is in the form of an obstruction theory, of somewhat wider application, formulated in terms of generalized …–algebras. This extends a program begun by… (More)
We investigate the fiber of a functor F : C → D between sketchable categories of algebras over an object D ∈ D from two points of view: characterizing its classifying space as a universal Aut(D)-space, and parametrizing its objects in cohomological terms.
We describe an obstruction theory for a given topological space X to be an H-space, in terms of higher homotopy operations, and show how this theory can be used to calculate such operations in certain cases.