• Publications
  • Influence
The AFD Sensory Neurons Encode Multiple Functions Underlying Thermotactic Behavior in Caenorhabditis elegans
TLDR
The physiological role of the AFD thermosensory neurons is studied by quantifying intracellular calcium dynamics in response to defined temperature stimuli and it is demonstrated that short-term adaptation allows AFD to sense temperature changes as small as 0.05°C over temperature ranges as wide as 10°C.
An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior
TLDR
It is shown that the AWC olfactory neurons respond to temperature, which suggests that the AFD and AWC neurons encode thermal stimuli via distinct strategies to regulate C. elegans thermotactic behavior.
The microarchitecture of C. elegans behavior during lethargus: homeostatic bout dynamics, a typical body posture, and regulation by a central neuron.
TLDR
The complex behavioral patterns and physiological activity of a command interneuron during lethargus can be dissected to quantifiable elements, which exhibit rich temporal dynamics and are actively regulated by the nervous system.
Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms
TLDR
Using tunable photo- and mechano-stimulation, two distinct categories of homeostatic responses during the sleep-like state of Caenorhabditis elegans are identified: response to strong stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not that of NPR-1, and response to weak stimuli did not require the function.
Sensorimotor control during isothermal tracking in Caenorhabditis elegans
TLDR
It is shown that sensorimotor control during isothermal tracking may be summarized as a strategy in which the worm changes the curvature of its propulsive undulations in response to temperature changes measured at its head, and that a concise mathematical model for this strategy is consistent with the exquisite stability of the worm's isothermal alignment in spatial thermal gradients.
A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
TLDR
The DGK-3 diacylglycerol kinase is identified as a thermal memory molecule that regulates the rate of TS resetting by modulating the temperature range of synaptic output, but not temperature sensitivity, of the AFD thermosensory neurons.
Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans
TLDR
Using long-term, high-resolution, longitudinal recordings of feeding dynamics under defined conditions, it is found that the frequency and duration of pumping bursts increase and the duration of long pauses diminishes in environments richer in bacteria.
Serotonin promotes exploitation in complex environments by accelerating decision-making
TLDR
The results implicate 5-HT in a novel form of decision-making, demonstrate its fitness consequences, suggest that NSM and ADF act in concert to modulate locomotion in complex environments, and identify the synergistic action of a channel and a metabotropic receptor in accelerating C. elegans decision- making.
...
1
2
3
4
...