David Barras

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Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked(More)
Metastases are responsible for most cancer-related deaths. One of the hallmarks of metastatic cells is increased motility and migration through extracellular matrixes. These processes rely on specific small GTPases, in particular those of the Rho family. Deleted in liver cancer-1 (DLC1) is a tumor suppressor that bears a RhoGAP activity. This protein is(More)
BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9/9L-dependent gene signature derived from independent mouse colorectal cancer (CRC) models unprecedentedly(More)
  • Frank Ellinger, Ieee Member, David Barras, Martin Schmatz, Heinz Jäckel
  • 2004
A low noise amplifier (LNA) for ultra wideband (UWB) and optical communication is presented in this paper. Active impedance matching allows a –3 dB bandwidth from dc to 7.8 GHz at 50 Ω port impedances. At a low power consumption of 1.8 V × 3.6 mA, the amplifier has a power gain of 10.6 dB, a noise figure below 4.4 dB, an input compression of –12 dBm and(More)
While T cell-based immunotherapies are steadily improving, there are still many patients who progress, despite T cell-infiltrated tumors. Emerging evidence suggests that T cells themselves may provoke immune escape of cancer cells. Here, we describe a well-controlled co-culture system for studying the dynamic T cell - cancer cell interplay, using human(More)
The successful targeting of neuroblastoma (NB) by associating tumor-initiating cells (TICs) is a major challenge in the development of new therapeutic strategies. The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional(More)
A compact testbed for real-time Ultra-Wideband (UWB) wireless system performance evaluation in terms of un-coded bit-error rate is presented. Both the transmitter and the receiver are realized in form of a small PCB. The system operates in the frequency range from 3.1--5.0 GHz with a maximum data rate of 10 MBit/s. By means of two examples this poster(More)
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