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BACKGROUND Phages, viruses that infect prokaryotes, are the most abundant microbes in the world. A major limitation to studying these viruses is the difficulty of cultivating the appropriate prokaryotic hosts. One way around this limitation is to directly clone and sequence shotgun libraries of uncultured viral communities (i.e., metagenomic analyses).(More)
Phage are the most abundant biological entities in the biosphere, with an estimated 10 31 particles on the planet. They also play a major role in carbon cycling; at least 25% of fixed carbon passes through phage. Their roles as predators of bacteria have important implications for possible marine CO 2 sequestration. Metagenomic analyses show that the(More)
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