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A Preformulation Strategy for the Selection of Penetration Enhancers for a Transungual Formulation
TLDR
The proposed preformulation strategy helps to select appropriate enhancers for optimum topical delivery and paves way towards an efficient topical formulation for passive transungual drug delivery.
Lateral Drug Diffusion in Human Nails
TLDR
Profound lateral diffusion of CPO was demonstrated and shown to reduce the in vitro passive transungual drug permeation and prolong the lag-time in human toenails, implying that during passive in vitro transungUAL permeation experiments, the peripheral nail around the area of drug application has to be kept to a minimum, in order to get reliable data which mimics the in vivo situation.
A NOVEL TRANSUNGUAL FORMULATION (NAIL PATCH) FOR DELIVERY OF CICLOPIROX OLAMINE INTO THE NAIL AND THE NAIL FOLDS
TLDR
The in vitro release profile shows greater than 80% of drug release within 2 h indicating that the drug release is not the rate limiting step in drug delivery, and patch showed significant increase in epidermal accumulation and transungual permeation flux compared to the commercial formulation.
Continuous Melt Granulation for Taste-Masking of Ibuprofen
TLDR
The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin-screw melt granulation (TSMG), an emerging, high-productivity, continuous process.
Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study.
TLDR
Topical acetaminophen would be a safe and effective over-the-counter medication for itch, according to in vitro skin permeability studies.
Forme pharmaceutique solide contenant de l'arabinogalactane
La presente invention concerne une forme pharmaceutique pour l'administration d'un agent therapeutique comprenant une matrice polymere comprenant de l'arabinogalactane et un agent therapeutique
Systeme d'administration transdermique d'une composition antiemetique
Systeme antiemetique transdermique, de preference sous forme d'un patch matriciel adherant a un medicament, le systeme comportant une quantite antiemetique efficace d'un antagoniste du recepteur de
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