David B. Wolfson

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—Optical label swapping of 10-Gb/s nonreturn-to-zero (NRZ) labels attached to 40-Gb/s return-to-zero payloads is demonstrated using payload envelope detection (PED) circuits based on 40-Gb/s clock recovery with nanosecond locking time. The circuits generate a digital envelope signal representing the payload location without having to process the 40-Gb/s(More)
In many medical experiments, data are collected across time, over a number of similar trials, or over a number of experimental units. As is the case of neuron spike train studies, these data may be in the form of counts of events per unit of time. These counts may be correlated within each trial. It is often of interest to know if the introduction of an(More)
Ecological and biological processes can change from one state to another once a threshold has been crossed in space or time. Threshold responses to incremental changes in underlying variables can characterize diverse processes from climate change to the desertification of arid lands from overgrazing. Simultaneously estimating the location of thresholds and(More)
There is a well-recognized association between dysontogenetic tumors of the spinal cord (including teratomas and enterogenous cysts) and dysraphic congenital spinal malformations. The authors present a case of an adult with an intramedullary mature teratoma (IMMT) at the level of C1-2 of the cord associated with dysraphic congenital spinal malformations.(More)
The pattern of deterioration in patients with Alzheimer's disease is highly variable within a given population. With recent speculation that the apolipoprotein E allele may influence rate of decline and claims that certain drugs may slow the course of the disease, there is a compelling need for sound statistical methodology to address these questions.(More)
A widely accepted hypothesis is that the initiation of multiple sclerosis occurs many years before the clinical onset of disease. Thus far, attempts to describe the characteristics of the latent period have depended entirely on ad hoc methods relying heavily on the results of migrant studies. Here, by introducing a stochastic model to describe the(More)
We evaluated performance characteristics of a laboratory-developed, non-invasive prenatal screening (NIPS) assay for fetal aneuploidies. This assay employs massively parallel shotgun sequencing with full automation. GC sequencing bias correction and statistical smoothing were performed to enhance discrimination of affected and unaffected pregnancies.(More)
Several targeted therapies have been approved for treatment of solid tumors. Identification of gene mutations that indicate response to these therapies is rapidly progressing. A 34-gene next-generation sequencing (NGS) panel, developed and validated by us, was evaluated to detect additional mutations in community-based cancer specimens initially sent to our(More)