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We have previously reported that the FAC1 protein is contained in hippocampal structures that resemble Hirano bodies. Hirano bodies are cytoplasmic inclusions containing actin filaments that are numerous in the hippocampus of many Alzheimer's disease patients. FAC1 is a developmentally regulated protein that is localized to the cytoplasm of neurons during… (More)
Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on the innate immune functionality of hematopoietic immune cells, non-hematopoietic cell populations - including epithelial and stromal cells - are now recognized as playing a key role in innate… (More)
[This corrects the article on p. 307 in vol. 4, PMID: 24137162.].
I enjoyed reading in the CMAJ about Dr. Blum's encounter with Dr. Wilder Penfield. 1 I recall first seeing Dr. Pen-field in the cafeteria at the Royal Victo-ria Hospital when I was a medical student (probably around 1970) and being somewhat awed by his presence. I had read The Second Career a few years before, and I also knew him by reputation , through the… (More)