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The future of high-performance computing is likely to rely on the ability to efficiently exploit huge amounts of parallelism. One way of taking advantage of this parallelism is to formulate problems as "embarrassingly parallel" Monte-Carlo simulations, which allow applications to achieve a linear speedup over multiple computational nodes, without requiring(More)
Menstrual, reproductive and contraceptive factors have been associated with risk of endometrial cancer in populations where the incidence of this tumor is high. To investigate associations between these factors in a low-risk population with a low prevalence of hormone replacement therapy, we conducted a cohort study among 267,400 women employed in the(More)
Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included(More)
BACKGROUND Among women who practice breast self-examination (BSE), breast cancers may be detected when they are at an earlier stage and are smaller than in women who do not practice BSE. However, the efficacy of breast self-examination for decreasing breast cancer mortality is unproven. This study was conducted to determine whether an intensive program of(More)
Data from a population-based case-control study of breast cancer in men were used to examine the hypothesis that occupational exposure to electromagnetic fields increases the risk of breast cancer. Incident cases (n = 227) diagnosed between 1983 and 1987 were obtained from 10 population-based cancer registries of the Surveillance, Epidemiology, and End(More)
The data of the population-based cancer registry in Harare, Zimbabwe, for 1993-1995 are presented and compared with those from 1990-1992. The most significant change in rates is the striking increase in the incidence of Kaposi's sarcoma (KS) in both men and women, compatible with the evolution of the AIDS epidemic in sub-Saharan Africa. The incidence of KS(More)
—In many application domains, data are represented using large graphs involving millions of vertices and billions of edges. Graph exploration algorithms, such as breadth-first search (BFS), are largely dominated by memory latency and are challenging to process efficiently. In this paper, we present a recon-figurable hardware methodology for efficient(More)
BACKGROUND Giant cell tumour of bone (GCTB) is a very rare, aggressive, and progressive osteolytic tumour for which no standard medicinal treatment or chemotherapy exists. We report interim safety and efficacy results from a phase 2 study of denosumab in patients with GCTB. METHODS We did an international, open-label, parallel-group, phase 2 trial of(More)
BACKGROUND A National Institutes of Health (NIH) Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma, held in June 1990, recommended breast conservation therapy for the majority of women with Stage I or II breast carcinoma. The authors evaluated the national use of breast conservation therapy before and(More)
OBJECTIVE To identify time trends and factors associated with breast-conserving surgery (BCS) and delivery of postoperative radiation therapy among women with stage I or II breast cancer. DESIGN Survey. SETTING Population-based cancer registry in the Seattle-Puget Sound (Wash) region. PARTICIPANTS The study included 8095 women diagnosed with stage I(More)