David B . Snead

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BACKGROUND Sirolimus-eluting stents reduce rates of restenosis and reintervention, as compared with uncoated stents. Data are limited regarding the safety and efficacy of such stents in primary percutaneous coronary intervention (PCI) for acute myocardial infarction with ST-segment elevation. METHODS We performed a single-blind, multicenter, prospectively(More)
The separate and combined effects of weight-bearing exercise and hormone replacement therapy (HRT) on bone mineral density (BMD) were studied in 32 women, 60 to 72 years of age. HRT consisted of continuous conjugated estrogens 0.625 mg/day and trimonthly medroxyprogesterone acetate 5 mg/day for 13 days. Exercise consisted of 2 months of low-intensity(More)
The effect of exercise modality on the relationship between ratings of perceived exertion (RPE), blood lactate concentration, oxygen uptake (VO2), and heart rate (HR) was examined in 29 untrained male subjects who completed counterbalanced VO2max/lactate threshold (LT) protocols on a cycle ergometer (CE) and treadmill (TM). Heart rate, VO2, and RPE were(More)
Fifteen male runners were tested on two occasions to determine the reliability of a continuous incremental level running treadmill protocol (C), with 3-min stages, for lactate threshold (LT) and fixed blood lactate concentration (FBLC) (2.0 mM, 2.5 mM, 4.0 mM) assessment. Test-retest (T-RT) reliability coefficients for velocity at LT, 2.0 mM, 2.5 mM, and(More)
The present study investigated the effect of training state on ratings of perceived exertion obtained at the lactate threshold (LT) and fixed blood lactate concentrations (FBLC) of 2.0, 2.5, and 4.0 mM. Runners (N = 20) and nonrunners (N = 29) completed a progressive horizontal treadmill (TM) running test which allowed identification of the TM velocities(More)
BACKGROUND This study evaluated a large group of patients enrolled in a double-blind randomized trial of the sirolimus-eluting stent to document whether the initial clinical improvement seen in previous smaller series is maintained out to 12 months and to study the potential treatment effect in patient subsets known to be at increased risk of restenosis. (More)
We examined the effects of training at and above the lactate threshold in previously untrained women. Twenty-four untrained eumenorrheic women (age = 31.3 +/- 4.0 yrs, wt = 66.2 +/- 7.6 kg, ht = 166.4 +/- 5.8 cm) were assessed at baseline [during days 1-3 of the menstrual cycle (MC)] and every 4 MC after that (for 1 year) for VO2 and velocity (V) at LT,(More)
BACKGROUND Drug-coated balloons (DCBs) have shown promise in improving the outcomes for patients with peripheral artery disease. We compared a paclitaxel-coated balloon with percutaneous transluminal angioplasty (PTA) for the treatment of symptomatic superficial femoral and popliteal artery disease. METHODS AND RESULTS The IN.PACT SFA Trial is a(More)
To determine the effects of cycle and run training on rating of perceived exertion at the lactate threshold (LT), college men completed a 40-session training program in 10 weeks (n=6 run training,n=5 cycle training,n=5 controls). Pre-and post-training variables were measured during graded exercise tests on both the bicycle ergometer and treadmill. ANOVA on(More)
To determine whether percent body fat (%BF) is overestimated in older people by hydrodensitometry (HD) because of an age-related decrease in bone mineral content (BMC), body composition of 113 women and 72 men (21-81 yr) was assessed by HD and dual-energy X-ray absorptiometry (DEXA). DEXA provides an estimate of %BF adjusted for differences in BMC. HD %BF(More)