David B. Parrish

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Clinical trials are studies in human patients to evaluate the safety and effectiveness of new therapies. Managing a clinical trial from its inception to completion typically involves multiple disparate applications facilitating activities such as trial design specification, clinical sites management, participants tracking, and trial data analysis. There(More)
Management of complex clinical trials involves coordinated-use of a myriad of software applications by trial personnel. The applications typically use distinct knowledge representations and generate enormous amount of information during the course of a trial. It becomes vital that the applications exchange trial semantics in order for efficient management(More)
To characterize further the nature of haemostatic impairment in haemorrhagic fever with renal syndrome, we assessed platelet function in 9 patients in whom the diagnosis was serologically confirmed. Defective platelet aggregation was demonstrated in every patient. An abnormality of the granule release reaction was demonstrated in all of 7 patients tested.(More)
  • D B Parrish
  • CRC critical reviews in food science and…
  • 1979
Determining vitamin D content in foods is difficult because in natural foods of highest vitamin D activity, and even in vitamin D-fortified foods, only small quantities are present, and many other compounds are extracted along with vitamin D that cause difficulties in purifying the extract or in the spectrophotometry or colorimetry that follows. Several(More)
Managing time-stamped data is essential to clinical research activities and often requires the use of considerable domain knowledge. Adequately representing and integrating temporal data and domain knowledge is difficult with the database technologies used in most clinical research systems. There is often a disconnect between the database representation of(More)
The increasing complexity of clinical trials has generated an enormous requirement for knowledge and information specification at all stages of the trials, including planning, documentation, implementation, and analysis. We are building a knowledge-based framework (Epoch) to support the management of clinical trials. We are tailoring this approach to the(More)
Software applications that work with biomedical data have significant knowledge-management requirements. Formal knowledge models and knowledge-based methods can be very useful in meeting these requirements. However, most biomedical data are stored in relational databases, a practice that will continue for the foreseeable future. Using these data in(More)
  • D B Parrish
  • Critical reviews in food science and nutrition
  • 1980
The vitamin E group includes tocopherols and tocotrienols and their isomers, esters, and derivatives. They differ not only in biopotencies as antisterility agents but also in activities in other physiological and chemical relationships. Unlike vitamins A and D, foods (vegetable oils) are among the richest sources of vitamin E, and assay methods for vitamin(More)