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A growing number of applications seek to incorporate automatically generated narrative structure into interactive virtual environments. In this paper, we evaluate a representation for narrative structure generated by an automatic planning system by 1) mapping the plans that control plot into conceptual graphs used by QUEST, an existing framework for(More)
Ewing sarcoma (ES) is an aggressive malignancy driven by an oncogenic fusion protein, EWS-FLI1. Neuropeptide Y (NPY), and two of its receptors, Y1R and Y5R are up-regulated by EWS-FLI1 and abundantly expressed in ES cells. Paradoxically, NPY acting via Y1R and Y5R stimulates ES cell death. Here, we demonstrate that these growth-inhibitory actions of NPY are(More)
INTRODUCTION Preclinical evaluation of delayed ventricular repolarization manifests electrocardiographically as QT interval prolongation and is routinely used as an indicator of potential risk for pro-arrhythmia (potential to cause Torsades de Pointes) of novel human pharmaceuticals. In accordance with ICH S7A and S7B guidelines we evaluated the sensitivity(More)
This paper describes a novel approach to human-robot interaction, in which a user modifies a robot's environment to constrain its actions, rather than programming its controller. An HRI simulation of a maze navigation task is presented. An empirical evaluation shows that for this task, users prefer an environment modification strategy rather than a(More)
M odern historiography has not fully appreciated the ecological complexity of the Silk Roads. As a result, it has failed to understand their antiquity, or to grasp their full importance in Eurasian history. The role played by the Silk Roads in exchanging goods, technologies , and ideas between regions of agrarian civilization is well understood. Less well(More)
Trust between agents is a well-studied concern for multiagent systems, but its counterpart, deception, deserves as much attention. In our area of research, interactive narrative generation, the study of deception is critical to the development of interesting and interactive stories.We describe an algorithm that explains how a deceiving agent might deceive a(More)
A first-person perspective role-playing game by its very nature attempts to create a sense of presence by fostering a deep connection between a user and her avatar. However, the current communication interfaces found within such environments endanger this connection by both forcing the player to consider the interface instead of the game and removing(More)
Neuroblastoma (NB) is a pediatric tumor of neural crest origin with heterogeneous phenotypes. Although low-stage tumors carry a favorable prognosis, >50% of high-risk NB relapses after treatment with a fatal outcome. Thus developing therapies targeting refractory NB remains an unsolved clinical problem. Brain-derived neurotrophic factor (BDNF) and its TrkB(More)
Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein driving ES transformation, neuropeptide Y (NPY) is highly expressed and(More)
CHRISTIAN, DAVID B. Strategic Deception in Agents. (Under the direction of Assistant Professor R. Michael Young). Despite its negative ethical connotations, deception is a useful tool for human social interaction, and plays an important role in the process of creating the stories that pervade our popular culture. In this paper, we describe the deception(More)