David Aragão

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The assembly and regulation of viral capsid proteins into highly ordered macromolecular complexes is essential for viral replication. Here, we utilize crystal structures of the capsid protein from the smallest and simplest known viruses capable of autonomously replicating in animal cells, circoviruses, to establish structural and mechanistic insights into(More)
MX1 is a bending-magnet crystallography beamline at the 3 GeV Australian Synchrotron. The beamline delivers hard X-rays in the energy range from 8 to 18 keV to a focal spot at the sample position of 120 µm FWHM. The beamline endstation and ancillary equipment facilitate local and remote access for both chemical and biological macromolecular crystallography.(More)
The design, deployment and execution of business process models and their associated security models is expensive and time consuming. This is because these activities usually involve multiple stakeholders that include business domain experts, security experts, web service developers and IT operations teams, and there is no streamlined development(More)
The Store.Synchrotron service, a fully functional, cloud computing-based solution to raw X-ray data archiving and dissemination at the Australian Synchrotron, is described. The service automatically receives and archives raw diffraction data, related metadata and preliminary results of automated data-processing workflows. Data are able to be shared with(More)
Machine-to-machine communication (M2M) is a technology to provide information exchange between devices without human intervention. Due to infrastructure characteristics, LTE networks are highly expected to become the deployment network of M2M devices. The integration of the M2M technology in LTE plays an important role in the development of applications for(More)
Mycobacteria contain a large number of highly divergent species and exhibit unusual lipid metabolism profiles, believed to play important roles in immune invasion. Thioesterases modulate lipid metabolism through the hydrolysis of activated fatty-acyl CoAs; multiple copies are present in mycobacteria, yet many remain uncharacterized. Here, we undertake a(More)
Machine-to-machine communication (M2M) is a core element for the Internet of Things (IoT). The Long-Term Evolution-Advanced (LTE-A) is expected to become a potential access network for M2M devices. However, M2M communication poses some challenges to LTE-A, with highlight to the congestion and overload problems in the Radio Access Network (RAN) during the(More)
Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional respiratory complex I in neuromuscular disorders. NDH-2 is a single-subunit monotopic membrane protein with just a flavin cofactor, yet(More)