David Anderson

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Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC, March 25-26, 1999, an expert panel met to develop guidelines for the use of the single-cell gel (SCG)/Comet assay in genetic toxicology. The expert panel reached a consensus that the optimal version of the Comet assay for identifying agents with genotoxic activity(More)
Dynamic languages such as JavaScript are more difficult to compile than statically typed ones. Since no concrete type information is available, traditional compilers need to emit generic code that can handle all possible type combinations at runtime. We present an alternative compilation technique for dynamically-typed languages that identifies frequently(More)
We briefly outline the information-theoretic (I-T) approaches to valid inference including a review of some simple methods for making formal inference from all the hypotheses in the model set (multimodel inference). The I-T approaches can replace the usual t tests and ANOVA tables that are so inferentially limited, but still commonly used. The I-T methods(More)
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BACKGROUND Patients who have a first episode of venous thromboembolism in the absence of known risk factors for thrombosis (idiopathic thrombosis) are often treated with anticoagulant therapy for three months. Such patients may benefit from longer treatment, however, because they appear to have an increased risk of recurrence after anticoagulant therapy is(More)
BACKGROUND Several diagnostic strategies using ultrasound imaging, measurement of D-dimer, and assessment of clinical probability of disease have proved safe in patients with suspected deep-vein thrombosis, but they have not been compared in randomized trials. METHODS Outpatients presenting with suspected lower-extremity deep-vein thrombosis were(More)
BACKGROUND Many patients with the antiphospholipid antibody syndrome and recurrent thrombosis receive doses of warfarin adjusted to achieve an international normalized ratio (INR) of more than 3.0. However, there are no prospective data to support this approach to thromboprophylaxis. METHODS We performed a randomized, double-blind trial in which patients(More)
We have previously demonstrated that a clinical model can be safely used in a management strategy in patients with suspected pulmonary embolism (PE). We sought to simplify the clinical model and determine a scoring system, that when combined with D-dimer results, would safely exclude PE without the need for other tests, in a large proportion of patients. We(More)
The effects of antioxidants and various other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes have been investigated using the COMET assay. Hydrogen peroxide (H2O2) and bleomycin (BLM) have produced clear dose-related responses. In 38 independent experiments, there was consistency between the two donors used in the study for the(More)
2001;119;22S-38S Chest Leon Poller, Alan Jacobson, Daniel Deykin and David Matchar Jack Ansell, Jack Hirsh, James Dalen, Henry Bussey, David Anderson, Managing Oral Anticoagulant Therapy l.html http://chestjournal.chestpubs.org/content/119/1_suppl/22S.ful and services can be found online on the World Wide Web at: The online version of this article, along(More)