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A new internal structure for simple polygons, the straight s k eleton, is introduced and discussed. It is composed of pieces of angular bisectores which partition the interior of a given n-gon P in a tree-like fashion into n monotone polygons. Its straight-line structure and its lower combinatorial complexity may make the straight skeleton preferable to the(More)
The contributions of this paper are both of theoretical and of experimental nature. From the experimental point of view, we conduct an empirical study on some dynamic connectivity algorithms which where developed recently. In particular, the following implementations were tested and compared with simple algorithms: simple sparsification by Eppstein et al.(More)
BACKGROUND AND OBJECTIVES Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). STUDY DESIGN/MATERIALS AND METHODS OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site(More)
The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit(More)
95 clinical trials of anticancer drugs were done in 40 patients with advanced ovarian cancer who had undergone an in-vitro soft-agar human tumour stem-cell assay for drug sensitivity. In the 95 clinical trials, 13 of 21 patients responded clinically to drugs predicted to be effective in vitro, while in 73 of 74 instances in which drug resistance had been(More)
The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the majority of cancers overexpressing COX-2; however, the role of COX-2 in the development of colorectal adenomas is less well defined. Accordingly, we analyzed 108 colorectal adenomas for COX-1 and COX-2 transcription in archival formalin-fixed, paraffin-embedded tissue using(More)
A graph drawing algorithm produces a layout of a graph in two-or three-dimensional space that should be readable and easy to understand. Since the aesthetic criteria diier from one application area to another, it is unlikely that a deenition of the \optimal drawing" of a graph in a strict mathematical sense exists. A large number of graph drawing algorithms(More)
The EVI-1 gene was originally detected as an ectopic viral insertion site and encodes a nuclear zinc finger DNA-binding protein. Previous studies showed restricted EVI-1 RNA or protein expression during ontogeny; in a kidney and an endometrial carcinoma cell line; and in normal murine oocytes and kidney cells. EVI-1 expression was also detected in a subset(More)