Background: Activation of inflammatory pathways plays an important contributory role in coronary plaque instability and subsequent rupture, which can lead to the development of acute coronary syndrome (ACS). Elevated levels of serum inflammatory markers such as C-reactive protein (CRP) represent independent risk factors for further cardiovascular events.… (More)
Combined atrial septal defect and pulmonic or aortic stenosis are relatively uncommon conditions in adult patients, with few reported cases of percutaneous treatment. We present two patients with secundum type atrial septal defect and concomitant pulmonic or aortic stenosis and their treatment by transcatheter techniques.
In spite of many years of development and implementation of pre-hospital advanced life support programmes, the survival rate of out-of-hospital cardiac arrest (OHCA) used to be very poor. Neurologic injury from cerebral hypoxia is the most common cause of death in patients with OHCA. In the past two decades, post-resuscitation care has developed many new… (More)
Original approval signatures are on file with the University of Oregon Graduate School. Dynamic regulation of the actin cytoskeleton is required for synapses to form and maintain their shape. The actin cytoskeleton is regulated by Rho GTPases in response to genetic and extracellular signals. Rho GTPases are regulated by guanine nucleotide exchange factors… (More)
BACKGROUND Statins have been proved to be effective in reduction of mortality and morbidity when started in the early secondary prevention in stabilized patients after acute coronary syndrome (ACS). The safety and efficacy of statin administration directly in the first-line therapy in unstable ACS patients is not clear. The aim of our study was, therefore,… (More)
There is an overwhelming amount of empirical evidence that democracy makes states more pacific toward their citizens. This robust finding has left scholars working in this area confident that they know why democracy causes states to be more pacific. I argue this is not true for two reasons. First, the theories adopted to explain this relationship have not… (More)
Since the late 1980's there has been a major resurgence in electric vehicle propulsion research and development. This trend has been stimulated by various factors, including rising fossil fuel costs, environmental concerns, and developments in technologies, such as improved permanent magnets, switching transistors and storage batteries. New technology has… (More)