David A. Rhodes

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Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.

Leo C James, Anthony H Keeble, Zahra Khan, David A. Rhodes, John Trowsdale
Proceedings of the National Academy of Sciences…
2007

The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved… (More)

Louise H Boyle, Clemens Hermann, +9 authors John Trowsdale
Proceedings of the National Academy of Sciences…
2013

Tapasin is an integral component of the peptide-loading complex (PLC) important for efficient peptide loading onto MHC class I molecules. We investigated the function of the tapasin-related protein,… (More)

TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain.

David A. Rhodes, John Trowsdale
Molecular immunology
2007

TRIMs comprise a large protein family that include anti-retroviral restriction factors such as TRIM5alpha. Auto-antibodies to TRIM21 (Ro52) are a common serological feature of patients with Sjogren's… (More)

Contribution of CoA ligases to benzenoid biosynthesis in petunia flowers.

Antje Klempien, Yasuhisa Kaminaga, +11 authors Natalia Dudareva
The Plant cell
2012

Biosynthesis of benzoic acid from Phe requires shortening of the side chain by two carbons, which can occur via the β-oxidative or nonoxidative pathways. The first step in the β-oxidative pathway is… (More)

BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

Isobel A. Smith, Brittany R. Knezevic, +5 authors John Trowsdale
Journal of immunology
2010

Butyrophilin (BTN) genes encode a set of related proteins. Studies in mice have shown that one of these, BTN1A1, is required for milk lipid secretion in lactation, whereas butyrophilin-like 2 is a… (More)

Regulation of Immunity by Butyrophilins.

David A. Rhodes, Walter Reith, John Trowsdale
Annual review of immunology
2016

Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk. They are considered to be members of the B7 family of costimulatory… (More)

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?

David A. Rhodes, Bernard de Bono, John Trowsdale
Immunology
2005

SPRY and B30.2 are homologous domains which can be identified in 11 protein families encoded in the human genome. These include cell surface receptors of the immunoglobulin super-family (BTNs),… (More)

The cluster of BTN genes in the extended major histocompatibility complex.

David A. Rhodes, Melanie Stammers, Georg Malcherek, Stephan Beck, John Trowsdale
Genomics
2001

We sequenced the 170-kb cluster of BTN genes in the extended major histocompatibility complex region, 4 Mb telomeric of human leukocyte antigen class I genes, at 6p22.1. The cluster consists of seven… (More)

RNAi suppression of Arogenate Dehydratase1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petals.

Hiroshi A Maeda, Ajit K. Shasany, +6 authors Natalia Dudareva
The Plant cell
2010

l-Phe, a protein building block and precursor of numerous phenolic compounds, is synthesized from prephenate via an arogenate and/or phenylpyruvate route in which arogenate dehydratase (ADT) or… (More)

Activation of Human γδ T Cells by Cytosolic Interactions of BTN3A1 with Soluble Phosphoantigens and the Cytoskeletal Adaptor Periplakin

David A. Rhodes, Chih Jung Chen, +5 authors John Trowsdale
Journal of immunology
2015

The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A1 controls… (More)

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