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- Stephen D. Bentley, Keith F. Chater, +40 authors David A. Hopwood
- Nature
- 2002
Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we… (More)
- Matthias Redenbach, Helen M. Kieser, +4 authors David A. Hopwood
- Molecular microbiology
- 1996
A Supercos-1 library carrying chromosomal DNA of a plasmid-free derivative of Streptomyces coelicolor A3(2) was organized into an ordered encyclopaedia of overlapping clones by hybridization. The… (More)
- Sébastien Rigali, Fritz Titgemeyer, +4 authors Gilles P. van Wezel
- EMBO reports
- 2008
Members of the soil-dwelling prokaryotic genus Streptomyces produce many secondary metabolites, including antibiotics and anti-tumour agents. Their formation is coupled with the onset of development,… (More)
- Tobias Kieser, Mervyn Bibb, +4 authors M Buttner
- 2000
Novel genetic tools for diaminopimelic acid selection in virulence studies of Practical Streptomyces genetics. Molecular cloning: a laboratory manual. 3rd ed. Practical streptomyces genetics. T… (More)
- Y. S. Lin, Helen M. Kieser, David A. Hopwood, Carton W. Chen
- Molecular microbiology
- 1994
- Tobias Kieser, David A. Hopwood, Helen M. Wright, Charles J. Thompson
- Molecular and General Genetics MGG
- 1982
SummaryStreptomyces lividans ISP 5434 contains four small high copy number plasmids: pIJ101 (8.9 kb), pIJ102 (4.0 kb), pIJ103 (3.9 kb) and pIJ104 (4.9 kb). The three smaller species appear to be… (More)
- David A. Hopwood, Tobias Kieser, Helen M. Wright, Mervyn Bibb
- Journal of general microbiology
- 1983
Streptomyces lividans 66 was shown to harbour two self-transmissible plasmids: SLP2, which acts as a sex factor, and SLP3. Derivatives of this strain which had lost both plasmids were used as host… (More)
The actII region, flanked by biosynthetic genes in the 25 kb act cluster of S. coelicolor, consists of four open reading frames, including a transcriptional activator for the biosynthetic genes, and… (More)
- Gregory L Challis, David A. Hopwood
- Proceedings of the National Academy of Sciences…
- 2003
In this article we briefly review theories about the ecological roles of microbial secondary metabolites and discuss the prevalence of multiple secondary metabolite production by strains of… (More)
- Sébastien Rigali, Harald Nothaft, +8 authors Giles P van Wezel
- Molecular microbiology
- 2006
Members of the soil-dwelling, sporulating prokaryotic genus Streptomyces are indispensable for the recycling of the most abundant polysaccharides on earth (cellulose and chitin), and produce a wide… (More)