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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

• Cindy S Ma, Gary Y. J. Chew, +6 authors Matthew C. Cook
• The Journal of experimental medicine
• 2008

Hyper-immunoglobulin E syndrome (HIES) is a primary immune deficiency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus… (More)

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

• Nicholas S. Simpson, Paul A. Gatenby, +10 authors Matthew C. Cook
• Arthritis and rheumatism
• 2010

OBJECTIVE In the sanroque mouse model of lupus, pathologic germinal centers (GCs) arise due to increased numbers of follicular helper T (Tfh) cells, resulting in high-affinity anti-double-stranded… (More)

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

• Danielle T Avery, Elissa K Deenick, +26 authors Stuart G Tangye
• The Journal of experimental medicine
• 2010

Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte… (More)

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

• Cindy S Ma, Danielle T Avery, +22 authors Stuart G Tangye
• Blood
• 2012

T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the… (More)

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

• Marcel L Batten, Nandhini Ramamoorthi, +12 authors Nico Ghilardi
• The Journal of experimental medicine
• 2010

Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on support from T follicular helper (T(FH)) cells. T(FH) cells are characterized by their localization to… (More)

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

• S anee Suryani, David A. Fulcher, +6 authors Stuart G Tangye
• Blood
• 2010

The transitional stage of B-cell development represents an important step where autoreactive cells are deleted, allowing the generation of a mature functional B-cell repertoire. In mice, 3 subsets of… (More)

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.

• Cindy S Ma, Natalie Wong, +47 authors Stuart G Tangye
• The Journal of allergy and clinical immunology
• 2015

BACKGROUND Follicular helper T (TFH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. TFH cells also contribute to human immune disorders, such as autoimmunity,… (More)

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

• Suzanne B. Hartley, Michael P. Cooke, +4 authors Christopher C. Goodnow
• Cell
• 1993

In transgenic mice, self-reactive B lymphocytes are eliminated if they encounter membrane-bound self antigens during their development within the bone marrow. We show here that two separate and… (More)

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help

• David A. Fulcher, Alan Bruce Lyons, +5 authors Antony Basten
• The Journal of experimental medicine
• 1996

Self-reactive B cells from tolerant double-transgenic (Dbl-Tg) mice coexpressing hen egg lysozyme (HEL) and rearranged anti-HEL immunoglobulin genes have a relatively short life span when compared to… (More)

Reduced life span of anergic self-reactive B cells in a double- transgenic model

• David A. Fulcher, Antony Basten
• The Journal of experimental medicine
• 1994

The life span of anergic self-reactive B cells was determined by 5-bromo-2'-deoxyuridine (BrdU) loading of tolerant double-transgenic (Dbl-Tg) mice produced by mating hen egg lysozyme… (More)

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