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We describe two applications that illustrate the idea of <italic>computational wear</italic> in the domain of document processing. By graphically depicting the history of author and reader interactions with documents, these applications offer otherwise unavailable information to guide work. We discuss how their design accords with a theory of professional(More)
Luke is a knowledge editor designed to support two tasks; the first is editing the classes and relations in a knowledge base. The second is editing and maintaining the semantic mapping knowledge neccesery to allow a natural language interface to understand sentences with respect to that knowledge base. In order to emphasize design decisions shared between(More)
Although the introduction of selective v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors has been a major advance in treatment of metastatic melanoma, approximately 50% of patients have limited responses including stabilization of disease or no response at all. This study aims to identify a novel means of overcoming resistance of melanoma to(More)
A new generation of knowledge/databases is emerging. These systems contain thousands of objects, densely interconnected and heterogeneously organized, entered from many sources, both human and automated. Such systems present tremendous challenges to their users, who must locate relevant information quickly and add new information effectively. Our research(More)
Past studies have shown that melanoma cells have largely adapted to endoplasmic reticulum (ER) stress, and this is associated with up-regulation of the antiapoptotic proteins Bcl-2 and Mcl-1. In this report, we show that the BH3 mimetic obatoclax potently overcomes resistance of melanoma cells to apoptosis induced by ER stress. Obatoclax, as a single agent(More)
Complex tasks consist of many threads of activity to remember and coordinate. Managing these threads is a significant part of problem solving. Our research attempts to find ways to assist this process. In this paper we present DETENTE, an object-oriented system to embed agendas in complex application interfaces. THE COMPUTER MAINTENANCE DOMAIN Keeping(More)
Anti-apoptotic Bcl-2 family proteins, in particular, Mcl-1, are known to play a critical role in resistance of human melanoma cells to induction of apoptosis by endoplasmic reticulum stress and other agents. The present study examined whether the BH3 mimetics, Obatoclax and ABT-737, which inhibit multiple anti-apoptotic Bcl-2 family proteins, would overcome(More)
Spirograms were obtained before and after emergency therapy in 85 episodes of acute bronchial asthma in 82 patients. The clinical status of all patients after emergency treatment was reevaluated 48 hours later. Patients could be divided into three groups: I) admissions; II) patients discharged but with later respiratory problems; and III) patients who were(More)