David A. Wroblewski

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We describe two applications that illustrate the idea of <italic>computational wear</italic> in the domain of document processing. By graphically depicting the history of author and reader interactions with documents, these applications offer otherwise unavailable information to guide work. We discuss how their design accords with a theory of professional(More)
Although the introduction of selective v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors has been a major advance in treatment of metastatic melanoma, approximately 50% of patients have limited responses including stabilization of disease or no response at all. This study aims to identify a novel means of overcoming resistance of melanoma to(More)
Past studies have shown that melanoma cells have largely adapted to endoplasmic reticulum (ER) stress, and this is associated with up-regulation of the antiapoptotic proteins Bcl-2 and Mcl-1. In this report, we show that the BH3 mimetic obatoclax potently overcomes resistance of melanoma cells to apoptosis induced by ER stress. Obatoclax, as a single agent(More)
Collateral resistance to cisplatin and methotrexate has been reported in several cell lines. A murine leukemia cell line (L1210/DDP) selected for cisplatin resistance also has been shown to be highly resistant to methotrexate. Of the mechanisms proposed for methotrexate resistance, only changes in methotrexate transport into the cells were found in an(More)
This paper introduces, motivates, and illustrates an approach to the construction of intelligent assistance systems that we call collaborative manipulation. We show how a system can offer effective assistance through collaborative manipulation of objects in a shared workspace. We have developed this approach through experience with an intelligent knowledge(More)
Anti-apoptotic Bcl-2 family proteins, in particular, Mcl-1, are known to play a critical role in resistance of human melanoma cells to induction of apoptosis by endoplasmic reticulum stress and other agents. The present study examined whether the BH3 mimetics, Obatoclax and ABT-737, which inhibit multiple anti-apoptotic Bcl-2 family proteins, would overcome(More)
During a five-year period, cultures of bronchial washings for Mycobacterium tuberculosis were obtained almost routinely (859 of 1,012 bronchoscopic examinations.). This practice proved costly, and the diagnostic yield was extremely low. Only three cases were diagnosed solely by this method (0.35 percent). Five other cases were false-positive. Additionally,(More)
Luke is a knowledge editor designed to support two tasks; the first is editing the classes and relations in a knowledge base. The second is editing and maintaining the semantic mapping knowledge neccesery to allow a natural language interface to understand sentences with respect to that knowledge base. In order to emphasize design decisions shared between(More)