David A. Shiba

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The arenesulfonylhydrazones of 2-pyridinecarboxaldehyde 1-oxide represent a relatively new class of anticancer agents. The biochemical alterations responsible for antineoplastic activity were investigated using the most potent member of this class synthesized to date, the 3,4-dimethoxybenzenesulfonylhy-drazone of 2-pyridinecarboxaldehyde 1-oxide (3,4-DSP),(More)
The arenesulfonylhydrazones of 2-pyridinecarboxaldehyde 1-oxide represent a relatively new class of anticancer agents. The biochemical alterations responsible for antineoplastic activity were investigated using the most potent member of this class synthesized to date, the 3,4-dimethoxybenzenesulfonylhydrazone of 2-pyridinecarboxaldehyde 1-oxide (3,4-DSP),(More)
Primary cilia are microtubule-based organelles projecting from the surface of nearly all cells. Primary cilia are complex organelles and are structurally divided longitudinally into sub-compartments that include the basal body, the transitional zone, the ciliary shaft and the tip. Nephro-nophthisis (NPHP) is an autosomal recessive cystic kidney disease with(More)
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