David A. Schilling

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Heuristic concentration (HC) is a two-stage metaheuristic that can be applied to a wide variety of combinatorial problems. It is particularly suited to location problems in which the number of facilities is given in advance. In such settings, the ®rst stage of HC repeatedly applies some random-start interchange (or other) heuristic to produce a number of(More)
Undoubtedly, humans have been analyzing the effectiveness of locational decisions since they inhabited their first cave. We use the term " facility " here in its broadest sense. That is, it is meant to include entities such as air and mar-name but a few that have been analyzed in the research literature. The ubiquity of locational decision-making has led to(More)
This paper examines the implications of utilizing decision support systems (DSS) in the public sector based on a DSS developed and implemented for a community mental health system. The DSS includes a multiple objective (goal programming) allocation model and encompasses a multiple party decision process. The experiences and insights acquired during the(More)
PURPOSE Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa. MATERIALS AND(More)
BACKGROUND The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling is complex and cost-intensive. Formalin-fixed paraffin-embedded specimens (FFPE) are easy to handle and economic to store, but their(More)
AIMS/HYPOTHESIS In different cancers types, insulin receptor isoform composition or insulin receptor substrate (IRS) isoforms are different to healthy tissue. This may be a molecular link to increased cancer risk in diabetes and obesity. Since this is yet unclear for prostate cancer, we investigated IR isoform composition and IRS balance in prostate cancer(More)
As dose-escalation in prostate cancer radiotherapy improves cure rates, a major concern is rectal toxicity. We prospectively assessed an innovative approach of hydrogel injection between prostate and rectum to reduce the radiation dose to the rectum and thus side effects in dose-escalated prostate radiotherapy. Acute toxicity and planning parameters were(More)
Introduction. Several point-of-care tests (POCT) are available for the diagnosis of bladder cancer (BC). We evaluate the impact of HU (hematuria) on performance of POCTs. Materials and Methods. Urine from 10 donors was diluted with blood from 0.5 to 0.00625%. BladderCheck(R), BTAstat(R), BCM(R), and BTA(R) tests were applied. Tests were additionally(More)