David A Nagib

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Organofluorine compounds possess unique physical properties that are exploited in a wide range of applications such as dyes, polymers, agrochemicals, and pharmaceuticals. 1 In medicinal chemistry, for example, valuable physiological properties are often conferred on " drug-like " molecules via the incorporation of CF 3 groups that enhance binding(More)
Modern drug discovery relies on the continual development of synthetic methodology to address the many challenges associated with the design of new pharmaceutical agents. One such challenge arises from the enzymatic metabolism of drugs in vivo by cytochrome P450 oxidases, which use single-electron oxidative mechanisms to rapidly modify small molecules to(More)
The unique physical and chemical advantages conferred by the C À F bond have led to the broad exploitation of this motif throughout the pharmaceutical, [1] materials, [2] and agrochem-ical [3] sectors. In drug design, for instance, incorporation of polyfluorinated alkyl groups, such as CF 3 moieties, can profoundly impact the activity, metabolic stability,(More)
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