David A. McNeill

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The pulmonary tumor response of Strain A mice has been reported to be a rapid and efficient predictor of carcinogenic potential for a variety of chemicals. The route of exposure has usually been by intraperitoneal injection (i.p.) of solubilized materials. We compared intratracheal (i.t.) instillation as a more representative route typical of human(More)
A nickel subsulfide (Ni3S2) lung tumor model for the study of metal carcinogenesis was evaluated using intratracheally dosed B6C3F1 mice. A preliminary study of the survival of mice 14 days after a single intratracheal dose of Ni3S2 displayed an LD50 of 4 mg/kg. A lifetime study was then initiated using five graded doses of Ni3S2 or saline alone,(More)
Three experiments were conducted to assess the effects of magnesium deficiency on the activities of hepatic glucose-6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FDPase) and phosphoenolpyruvate carboxykinase (PEPCK). Experiment 1 was designed to determine if magnesium deficiency interfered with the gluconeogenic response to fasting. Rats were fed(More)
This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increase in pulmonary tumor response in this(More)
The increase in the invertase activity of extracts from freshly cut potato (Solanum tuberosum L.) by "foaming," caused by selective denaturation of an endogenous invertase inhibitor, did not occur in extracts made from thin disks 2 days after slicing. Rather, foaming such extracts decreased invertase activity. Apparently, the inhibitor disappeared after(More)
The amounts of magnesium, zinc, copper, and manganese in 22 health and vegetarian foods and their conventional counterparts were measured. Increased levels of magnesium were associated with the presence of soy in vegetarian and health products. Zinc was low in the vegetarian meat and egg substitutes and in soy milk. Copper tended to be decreased in the(More)
Proximate composition, edible yields, and selected nutrients were measured in cantaloupe, cherries, grapes, nectarines, plums, and watermelon sampled in six major U.S. markets. Yields were lowest (about 55%) for the melons, but were much higher (about 90% or above) for other fruits. Fruits were high in moisture, low in protein, fat, and energy. The(More)