David A. Lowe

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Abstract Rationale. Marijuana is known to have psychotropic effects in humans. In this study, we used rat models of sensorimotor gating, hyperactivity and stereotypy to explore whether CB1 receptor stimulation or blockade induces behavioral changes consistent with psychotomimetic or antipsychotic agents, respectively. Objectives. We determined whether (a)(More)
It is well established that nicotinic systems in the brain are critically involved in attentional processes in both animals and humans. The current study assessed the effects of a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist, R3487/MEM3454 (also referred to as R3487 or MEM 3454) on sustained attention in rats performing an operant(More)
The Lorentzian AdS/CFT correspondence implies a map between local operators in supergravity and non-local operators in the CFT. By explicit computation we construct CFT operators which are dual to local bulk fields in the semiclassical limit. The computation is done for general dimension in global, Poincaré and Rindler coordinates. We find that the CFT(More)
Neuronal nicotinic α7 acetylcholine receptors (α7nAChRs) are expressed primarily in the brain and are implicated in modulating many cognitive functions (e.g., attention, working and episodic memory). Not surprisingly, much effort has been committed to the development of molecules acting at α7nAChRs as potential therapies for a variety of central nervous(More)
We develop an approximation scheme for the quantum mechanics of N D0-branes at finite temperature in the 't Hooft large- N limit. The entropy of the quantum mechanics calculated using this approximation agrees well with the Bekenstein-Hawking entropy of a ten-dimensional nonextremal black hole with 0-brane charge. This result is in accordance with the(More)
We study brane configurations in the presence of orientifold six-planes. After deriving the curves for N = 2 supersymmetric SU(Nc) gauge theories with one flavor in the symmetric or antisymmetric representation and Nf fundamental flavors, we rotate the brane configuration, reducing the supersymmetry to N = 1. For the case of an antisymmetric flavor and less(More)
Effective treatments for cognitive impairment associated with schizophrenia (CIAS) remain an unmet need. Nicotinic α7 receptor agonists may be effective in CIAS. This 8-week (week 1, inpatient; weeks 2–8, outpatient), double-blind, randomized study used Measurement And Treatment Research to Improve Cognition in Schizophrenia (MATRICS) guidelines to(More)
Using a six-orientifold on top of a NS-fivebrane we construct a chiral N = 1 supersymmetric gauge theory in four dimensions with gauge group SU(Nc) and matter in the symmetric, antisymmetric and (anti)fundamental representations. Anomaly cancellation is fulfilled by the requirement of a smooth RR 7-form charge distribution and leads us to the introduction(More)