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- Elin Grundberg, Kerrin S. Small, Åsa K. Hedman, Alexandra C. Nica, Alfonso Buil, Sarah Keildson +45 others
- Nature genetics
- 2012

Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues conducted in a… (More)

A nonparametric Bayesian extension of Factor Analysis (FA) is proposed where observed data Y is modeled as a linear superposi-tion, G, of a potentially infinite number of hidden factors, X. The Indian Buffet Process (IBP) is used as a prior on G to incorporate sparsity and to allow the number of latent features to be inferred. The model's utility for… (More)

Variational Message Passing (VMP) is an algorithmic implementation of the Vari-ational Bayes (VB) method which applies only in the special case of conjugate exponential family models. We propose an extension to VMP, which we refer to as Non-conjugate Variational Message Passing (NCVMP) which aims to alleviate this restriction while maintaining modularity,… (More)

A nonparametric Bayesian extension of Independent Components Analysis (ICA) is proposed where observed data Y is modelled as a linear superposition, G, of a potentially infinite number of hidden sources, X. Whether a given source is active for a specific data point is specified by an infinite binary matrix, Z. The resulting sparse representation allows… (More)

Latent variable models for network data extract a summary of the relational structure underlying an observed network. The simplest possible models subdivide nodes of the network into clusters; the probability of a link between any two nodes then depends only on their cluster assignment. Currently available models can be classified by whether clusters are… (More)

We introduce a new regression framework, Gaussian process regression networks (GPRN), which combines the structural properties of Bayesian neural networks with the nonparametric flexibility of Gaussian processes. This model accommodates input dependent signal and noise correlations between multiple response variables, input dependent length-scales and… (More)

We propose a general algorithm for approximating nonstandard Bayesian posterior distributions. The algorithm minimizes the Kullback-Leibler divergence of an approximating distribution to the intractable posterior distribution. Our method can be used to approximate any posterior distribution, provided that it is given in closed form up to the proportionality… (More)

Nonparametric Bayesian models provide a framework for flexible probabilistic modelling of complex datasets. Unfortunately, the high-dimensional averages required for Bayesian methods can be slow, especially with the unbounded representations used by nonparametric models. We address the challenge of scaling Bayesian inference to the increasingly large… (More)

Factor analysis models effectively summarise the covariance structure of high dimensional data, but the solutions are typically hard to interpret. This motivates attempting to find a disjoint partition, i.e. a simple clustering, of observed variables into highly correlated subsets. We introduce a Bayesian non-parametric approach to this problem, and… (More)

WHAT: a probabilistic model to infer binary latent variables that preserve neighbourhood structure of the data • WHY: to perform a nearest neighbour search for the purpose of retrieval • WHEN: in dynamic and streaming nature of the Internet data