David A Huse

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We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical "tight-coupling" mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity,(More)
We use exact diagonalization to explore the many-body localization transition in a random-field spin-1/2 chain. We examine the correlations within each many-body eigenstate, looking at all high-energy states and thus effectively working at infinite temperature. For weak random field the eigenstates are thermal, as expected in this nonlocalized, “ergodic”(More)
We have studied the ordering dynamics of the striped patterns of a single layer of cylindrical block copolymer microdomains in a thin film. By tracking disclinations during annealing with time-lapse atomic force microscopy, we observe a dominant mechanism of disclination annihilation involving three or four disclinations (quadrupoles). Pairwise disclination(More)
We use the density matrix renormalization group to perform accurate calculations of the ground state of the nearest-neighbor quantum spin S = 1/2 Heisenberg antiferromagnet on the kagome lattice. We study this model on numerous long cylinders with circumferences up to 12 lattice spacings. Through a combination of very-low-energy and small finite-size(More)
We present an adaptive algorithm which optimizes the statistical-mechanical ensemble in a generalized broad-histogram Monte Carlo simulation to maximize the system's rate of round trips in total energy. The scaling of the mean round-trip time from the ground state to the maximum entropy state for this local-update method is found to be O ( [N ln N](2) ) for(More)
Arvind Murugan, 2 David A Huse, and Stanislas Leibler 4 Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540, U.S.A., SEAS, Harvard University, Cambridge, Massachusetts 02138, USA. Physics Department, Princeton University, Princeton, NJ 08544, U.S.A. Laboratory of Living Matter, The Rockefeller(More)
Shankar Iyer,1 Vadim Oganesyan,2,3,4 Gil Refael,1 and David A. Huse5 1Department of Physics, California Institute of Technology, MC 149-33, 1200 E. California Blvd., Pasadena, California 91125, USA 2Department of Engineering Science and Physics, College of Staten Island, CUNY, Staten Island, New York 10314, USA 3The Graduate Center, CUNY, 365 5th Ave., New(More)
Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and microtubule growth which share some of the(More)
Classical hard spheres crystallize at equilibrium at high enough density. Crystals made up of stackings of 2-dimensional hexagonal close-packed layers (e.g. fcc , hcp , etc.) differ in entropy by only about 10−3kB per sphere (all configurations are degenerate in energy). To readily resolve and study these small entropy differences, we have implemented two(More)
We have followed the coarsening dynamics of a single layer of cylindrical block copolymer microdomains in a thin film. This system has the symmetry of a two-dimensional smectic. The orientational correlation length of the microdomains was measured by scanning electron microscopy and found to grow with the average spacing between +/-1/2 disclinations,(More)