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N-Acetylcysteine (NAC) is a sulfhydryl-containing compound that produces a dramatic acceleration of urinary methylmercury (MeHg) excretion in poisoned mice, but the molecular mechanism for this effect is poorly defined. MeHg readily binds to NAC to form the MeHg-NAC complex, and recent studies indicate that this complex is an excellent substrate for the(More)
Aluminum salts or doses that are unlikely in the human system have been employed in toxicity studies and much attention had been focused on the secondary target (neurons) of its toxicity rather than the primary target (astroglia). In order to address these issues, we have investigated the uptake and apoptotic effects of aluminum amino acid complex on(More)
BACKGROUND Many people, by means of consumption of seafood or other anthropogenic sources, are exposed to levels of methylmercury (MeHg) that are generally considered to be quite low, but that may nevertheless produce irreversible brain damage, particularly in unborn babies. The only way to prevent or ameliorate MeHg toxicity is to enhance its elimination(More)
Citrate has been identified as a major tricarboxylic acid (TCA) cycle constituent preferentially released by astrocytes. We undertook the present study to examine further the nature of metabolic compartmentation in central nervous system tissues using 13C-labeled glucose and to provide new information on the influence of aluminum on the metabolic(More)
The present decade had witnessed an unprecedented attention focused on glial cells as a result of their unusual physiological roles that are being unraveled. It is now known that, rather than being a mere supporter of neurons, astroglia are actively involved in their modulation. The aluminum hypothesis seems to have been laid to rest, probably due to(More)
OBJECTIVES Aluminum is notorious as a neurotoxic metal. The aim of our study was to determine whether endoplasmic reticulum (ER) stress is involved in aluminum-induced apoptosis in astrocytes. METHODS Mitochondrial RNA (mRNA) was analyzed by reverse transcription (RT)-PCR following pulse exposure of aluminum glycinate to primary cultured astrocytes.(More)
The levels of some ions of heavy metals known to be associated with petroleum industry operations, including Pb, Ni, V, Cr, Cd, Zn and Fe, were studied in untreated groundwater from Warri area, Nigeria by atomic absorption spectroscopy. Warri area is characterized by petroleum industry activities including a Refinery. With this in mind, the residential area(More)
Mubi clay was investigated to examine if the deposit can be used as a furnace lining material. The result shows that the clay has a bulk density of 2.3g/cm 3 , apparent porosity of 13.70%, firing shrinkage of 9.6%, thermal shock resistance of 8 cycles, cold crushing strength of 253 kg/cm 2 , loss on ignition of 4% and refractoriness of 1,300 0 C. The(More)
Most of the developing nations like Nigeria intend to develop in a sustainable manner. This development cannot be realized if refrigerated-based air conditioning systems that are characterized by high power requirement, high cost and with a negative influence on t he environment are used as a means of achieving thermal comfort in living spaces. Evaporative(More)
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