Dave Rayner

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Energy dense, high fat, high sugar, foods and beverages in our diet are a major contributor to the escalating global obesity problem. Here, we examine the physiological and neuroendocrine effects of feeding rats a solid high-energy (HE) diet with or without a liquid supplement (Ensure) and the consequence of subsequently transferring animals back to chow(More)
Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on(More)
The influence of the cholecystokinin (CCK) antagonist L-364,718 (0.1 mg/kg) on short-term control of food intake was studied in 6 pigs. Arterial injection of L-364,718 abolished the inhibition of intake to CCK octapeptide infusion (4 micrograms/kg/hr; from 42% p less than 0.001, to 97% of control intake), but did not alter control intake (99%). Injection of(More)
Major regions of the rat brain have been examined for the presence of glucose transporters (GLUTs 1-4) and their mRNAs. Both the mRNA and immunoreactive protein for GLUT1 and GLUT3 were found in each brain region (medulla, pons, cerebellum, midbrain, hypothalamus, thalamus, hippocampus, parietal cortex). The mRNA and protein for GLUT4 were identified in the(More)
During the 1970ies and '80ies, the first computer communication networks were designed and implemented in the research and commercial sectors. Many of the protocols developed during that time are still in use today. This paper starts by giving an overview of these developments. Then it concentrates on the development of protocol engineering, that is, the(More)
Outbred male Sprague-Dawley rats were provided with one of the four flavours of the liquid diet, Ensure, in addition to chow pellets, to examine whether differences in flavour lead to differences in energy intake i.e. degree of over-consumption. For half the rats, the Ensure supplement was provided for 14 days and then withdrawn for the final 8 days of the(More)
The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride(More)
Models are used in metrology to characterise measurement data and, where appropriate, the process which produced that data. Indeed, modelling is a procedure designed to extract information from data. Therefore, for any proposed model, the question then arises: is the information provided by the model comprehensive and reliable? This question is resolved by(More)
This report describes three case studies of the testing of continuous modelling software. Where possible, the testing has been conducted by following the methodology outlined in the SSfM report " Testing Continuous Modelling Software " [1]. Where following this methodology has not been possible, the advice on alternative testing methods in the report [1](More)
Many experiments in metrology involve the use of instruments or measuring systems that measure values of a response variable corresponding to given values of a stimulus variable. The calibration of such instruments requires using a set of measurements of stimulus and response variables, along with their associated uncertainties, to determine estimates of(More)