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We compared the effects of glucose injection with those of saline or mannitol on ischemic brain damage and brain water content in a four-vessel occlusion (4-VO) rat model, which simultaneously causes severe forebrain ischemia and moderate hindbrain ischemia. Glucose given before onset of ischemia was followed by severe brain injury, with necrosis of the(More)
We studied 10 patients who survived for 2 to 8 weeks in a vegetative state, including 8 with cardiopulmonary failure and 2 with subarachnoid hemorrhage. Within days of onset, they regained brainstem function and awoke, but none had evidence of cognitive awareness. All patients opened their eyes within 2 weeks, and eight had roving conjugate eye movements.(More)
Seven-day postnatal rats were rendered hyperglycemic by the SC injection of 50% glucose, following which they were exposed to hypoxia with 8% oxygen. The glucose-treated animals survived more than twice as long as saline-treated littermates. Other hyperglycemic and control rat pups were subjected to hypoxia-ischemia by unilateral common carotid artery(More)
BACKGROUND AND PURPOSE Treating MS with disease-modifying drugs relies on accurate MR imaging follow-up to determine the treatment effect. We aimed to develop and validate a semiautomated software platform to facilitate detection of new lesions and improved lesions. MATERIALS AND METHODS We developed VisTarsier to assist manual comparison of volumetric(More)
Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CeD) case-control studies, using a rapid model-free approach to examine over 500 billion SNP(More)