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1. Studies of the effect of vagus nerve stimulation on ventricular myocardial function in mammals are limited, particularly in the human. 2. The present study was designed to determine the effect of direct electrical stimulation of the left vagus nerve on left ventricular contractile state in hearts paced at 10 % above the natural rate, in anaesthetised(More)
The objective of this study was to characterize the changes associated with intravenous infusions of large volumes of isotonic saline solution in rats so that effects of the infusion process could be more easily distinguished from effects of test articles. Male Sprague-Dawley rats weighing approximately 225-275 g at the beginning of the study were given(More)
Over the past decade, computing power has increased extraordinarily, enabling researchers to tackle large complex problems -- a great step forward in our ability to model the complex world. This increased capability resulted in massive amounts of data being produced and used by increasingly detailed simulations. It is the location, viewing, manipulation,(More)
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