Dave J Jones

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BACKGROUND Aortic aneurysm repair is a high-risk surgical procedure. Patients are often elderly, with multiple comorbidities that predispose them to perioperative morbidity. Use of endovascular aneurysm repair (EVAR) has increased due to reduced early perioperative risk. This study assessed whether preoperative cardiopulmonary exercise testing (CPET) could(More)
BACKGROUND Patients with non-tuberculous mycobacteria are usually started on conventional antituberculous triple therapy once acid fast bacilli are detected, before the exact type of mycobacteria has been identified. The ability to identify the characteristics of patients with tuberculous and non-tuberculous mycobacteria may be helpful in identifying before(More)
The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the neuritogenic-neurotoxic properties of this protein and relates them to possible aetiopathological mechanisms in AD. Marked differences in neuritic differentiation were detected when comparing untransfected(More)
Patients with chronic obstructive pulmonary disease (COPD) may benefit from ambulatory oxygen; however, the effect of exercise on arterial oxygen saturation (Sa,O2) in patients with kyphoscoliosis and of correction with ambulatory oxygen have not been previously reported. Twelve patients with stable kyphoscoliosis (mean (SD) Cobb angle 79 (26) degrees) were(More)
BACKGROUND Nasal mask discomfort is a major factor in compliance with treatment by nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (CPAP). METHODS A study of skin complications resulting from mask usage, with particular reference to predisposing factors, was carried out in 66 patients by means of a(More)
OBJECTIVE This study aimed to define the relationship between cardiorespiratory fitness and age in the context of postsurgery mortality and morbidity in older people. BACKGROUND Postsurgery mortality and morbidity increase with age. Cardiorespiratory fitness also declines with age, and the independent and linked associations between cardiorespiratory(More)
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