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A two-generation female reproduction and teratology study was undertaking using 0, 1.5 and 3.0 ppm of T-2 toxin in a semisynthetic diet. Conception rate was lowest at the first breeding and lowest in the control group at this time, but in later breedings the conception rates of each group were very similar. No significant differences were noted in litter(More)
Lambs received T-2 toxin at a rate of 0.6 or 0.3 mg/kg body weight per day in a protein reduced diet for 21 days to study the immunological and pathological effects of T-2 toxin in sheep. Blood was collected before T-2 treatment and on days 7, 14 and 21 of the trial for hematological and biochemical examination and for the separation of peripheral blood(More)
In a 16-month feeding study male and female CD-1 mice received semi-synthetic diets containing 0, 1.5 or 3.0 ppm T-2 toxin. Feed consumption, body-weight gains, clinical findings (including haematological examinations at 16 months) and the development of external lesions were recorded. At 3, 6, 12 and 16 months, animals were killed for assessment of their(More)
Mice were killed 2, 4, 6, 12, 24, 48 and 96 hours after intragastrical administration of 0, 5, 10, 20, or 40 mg/kg body weight of 3-acetyldeoxynivalenol. The animals became clinically ill after 12 hours and some animals in the highest dose group died. Histological examination of duodenal crypts, thymus and spleen revealed, in all dose groups, presence of(More)
3-Acetyldeoxynivalenol was incorporated into a semisynthetic diet at levels of 2.5, 5, 10 or 20 ppm and fed to mice for up to 48 days. Body weights and feed consumption were determined, and blood samples for hematological evaluation were taken. Selected tissues were examined microscopically and the humoral immune response was assessed using the Jerne plaque(More)
Successful return to play remains a challenge for a soccer player after anterior cruciate ligament reconstruction. In addition to a successful surgical intervention, a soccer-specific functional rehabilitation program is essential to achieve this goal. Soccer-like elements should be incorporated in the early stages of rehabilitation to provide neuromuscular(More)
Baccharinoid B4, Myrotoxin B and Roritoxin B, some recently identified macrocyclic trichothecenes, were tested in Swiss mice with respect to their toxicity after oral and topical application. For oral dosing, the mycotoxins were dissolved in propylene glycol, and doses from 0 to 8.0 mg/kg body weight (BW) were employed. For topical application, toxins were(More)
The comet assay is a sensitive and rapid method for detecting DNA single-strand and double-strand breaks and the individual cell's DNA repair profile. This pilot study was designed to determine whether the comet assay could measure inherited susceptibility to lung cancer. We applied the comet assay in the alkaline condition to test the DNA damage in(More)
Evidence has been mounting that trichothecenes cause cardiac lesions and cardiovascular effects in general. T-2 toxin, dissolved in dimethyl sulfoxide, was applied in doses of 0, 1.0, 2.0 mg/kg to the skin of Sprague-Dawley rats. Twenty-four hours later, the cardiac function of the animals was assessed, followed by killing and histological examination. It(More)