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BACKGROUND AND PURPOSE A potentially dangerous side effect associated with tissue plasminogen activator (tPA) use is cerebral hemorrhage. We have focused on developing drugs that could be administered with tPA to reduce the rate of hemorrhage. Since recent studies suggest that various matrix metalloproteinases (MMPs) are important in tumor necrosis(More)
BACKGROUND AND PURPOSE Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including excitotoxicity. The present study evaluated the pharmacological effects of DHEAS in a reversible spinal cord ischemia model. METHODS(More)
BACKGROUND AND PURPOSE Tissue plasminogen activator (tPA) is an effective treatment for stroke, but its utility is limited by fear of cerebral hemorrhage. Tenecteplase (TNK), a genetically modified form of wild-type tPA, exhibits a longer biological half-life and greater fibrin specificity, features that could lead to fewer cerebral hemorrhages than(More)
BACKGROUND AND PURPOSE It has been proposed that spin trap agents such as N:-t-butyl-phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia and stroke. However, to date, there is little information concerning the effectiveness of spin trap agents when administered in combination with the only Food and Drug(More)
and Duke conference on risk-neutral and objective probability measures provided many useful suggestions. A special thanks goes to Cam Harvey (the Editor) and an anonymous referee, whose suggestions have helped us improve this paper substantially. Kristaps Licis provided expert research assistance. Any errors are our own. An earlier version of this paper was(More)
anonymous referee, and seminar participants at the University of Texas at Austin for helpful comments. We are responsible for all remaining errors. ABSTRACT We compare CEOs of electric and gas utility firms to CEOs of unregulated firms. Utility CEOs tend to be older when appointed to office, have less prestigious educational backgrounds, and are more likely(More)
and the legion of volunteers and student interns without whom Seattle Community Court could not have served with such distinction-thank you for your dedication to doing the right thing. To the visionaries who are changing the Seattle and King County criminal justice system, thank you for your encouragement, support, and leadership. To the Downtown Seattle(More)