Learn More
A small molecule, alpha-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput screening as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM was used in combination with biochemical fractionation to identify a pathway that regulates mitochondria-initiated caspase activation. This pathway consists of tumor(More)
Manuscript accepted to Forest Ecology and Management, to be cited as " in press " Prepublication copy subject to some correction or change. Abstract Conservation of native fishes and changing patterns in wildfire and fuels are defining challenges for managers of forested landscapes in the western United States. Many species and populations of native fishes(More)
The international electrotechnical commission (IEC)-based term equipment protection levels (EPLs) refers to a process for identifying and selecting equipment for installation in hazardous (classified) locations. The process involves special equipment markings, an optional comprehensive risk assessment after area classification, and selection criteria to(More)
In the first of a five-part series on allergy, Dave Burns outlines the growing problem of allergic conditions. He suggests that in the UK, primary care services should manage allergic conditions but health professionals need education and training to do this effectively. This series aims to raise awareness of allergy and how allergic conditions should be(More)
Asthma is a common inflammatory condition affecting the airways. Many people with it fail to achieve a satisfactory level of control and, consequently, have recurrent acute exacerbations. These can occur due to allergen exposure, viral infections or for no identifiable reason. Guidelines categorise exacerbations into three categories, from moderate to life(More)
This paper discusses the generic view of defaecation and examines the mechanisms contributing to constipation. Although it is recognised that there are specific causes that will require medical intervention, for the purpose of this paper only the general clinical management will be addressed.
  • D Burns
  • 2007
Asthma and allergic rhinitis are two of the most common manifestations of allergy. The conditions have similar aetiologies, and genetic and environmental influences. There is increasing evidence that asthma and allergic rhinitis frequently co-exist, this article discusses the pharmacological management of these conditions, whether they exist independently(More)
  • 1