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A small molecule, alpha-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput screening as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM was used in combination with biochemical fractionation to identify a pathway that regulates mitochondria-initiated caspase activation. This pathway consists of tumor(More)
The international electrotechnical commission (IEC)-based term equipment protection levels (EPLs) refers to a process for identifying and selecting equipment for installation in hazardous (classified) locations. The process involves special equipment markings, an optional comprehensive risk assessment after area classification, and selection criteria to(More)
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