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High-throughput data production technologies, particularly 'next-generation' DNA sequencing, have ushered in widespread and disruptive changes to biomedical research. Making sense of the large datasets produced by these technologies requires sophisticated statistical and computational methods, as well as substantial computational power. This has led to an(More)
A factor IX polymorphism 5' to exon 2 was described as 1.70 versus 1.75 kb bands on Southern blots of Ddel digests (1). By primer directed polymerase chain reaction (PCR) amplification, the two alleles are readily apparent on agarose electrophoresis of undigested fragments (430 or 380 bp); in heterozygous women or amplified mixtures of two hemizygous male(More)
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