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The objective of this study was to determine the extent to which subjects modulate their elbow joint mechanical properties during ongoing arm movement. Small pseudo-random force disturbances were applied to the wrist with an airjet actuator while subjects executed large (1 rad) elbow joint movements. Using a lumped parameter model of the muscle, tendon and(More)
Motoneurons in the spinal cord have intrinsic voltage-dependent persistent inward currents (PICs; e.g. persistent calcium currents) that amplify synaptic inputs by three- to five-fold in addition to providing a sustained excitatory drive that allows motoneurons to fire repetitively following a brief synaptic excitation. In this study, we examined whether(More)
The stiffness of the human elbow joint was investigated during targeted, 1.0-rad voluntary flexion movements at speeds ranging from slow (1.5 rad/s) to very fast (6.0 rad/s). A torque motor produced controlled step position errors in the execution of the movements. The steps began at the onset of movement, rose to an amplitude of 0.15 rad in 100 ms, and had(More)
Previous findings have indicated that the recall of a recently studied word is affected by how many associates it has in long-term memory (set size). The purpose of these experiments was to determine whether recall is also affected by the connectivity of these associates. Studied words were preselected to represent combinations of set size and connectivity(More)
1. The responsiveness of the stretch reflex is modulated during human voluntary limb movements. The influence of this modulation on the limb mechanical properties (stiffness) was investigated. 2. Subjects were taught to replicate accurately a rapid (4.0 rad s-1) targeted elbow flexion movement of 1 rad. From the onset of 12% of the trials a sinusoidal(More)
OBJECTIVE To determine the incidence and clinical significance of neutralizing antibody (NAb) formation in patients with relapsing multiple sclerosis (MS) who participated in the European Interferon Beta-1a IM Dose-Comparison Study. METHODS Patients were randomized to treatment with interferon beta-1a (IFNbeta-1a) 30 microg or 60 microg IM once weekly for(More)
Many-cache is a memory architecture that efficiently supports caching in commercially available FPGAs. It facilitates FPGA programming for high-performance computing (HPC) developers by providing them with memory performance that is greater and power consumption that is less than their current CPU platforms, but without sacrificing their familiar, C-based(More)
This poster describes CHiMPS, a toolflow that aims to provide software developers with a way to program hybrid CPU-FPGA platforms using familiar tools, languages, and techniques. CHiMPS starts with C and produces a specialized spatial dataflow architecture that supports coherent caches and the shared-memory programming model. The toolflow is designed to(More)
Cued recall is strongly affected by the strength of the preexisting connection between the test cue and the information to be recalled, the target. In all past work, preexisting cue-to-target strength has been measured by the probability that the cue produced the target in free association. This paper presents four experiments showing that this use of such(More)