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Diversity‐Oriented Synthesis of Calothrixins and Ellipticines
The divergent synthesis of calothrixins and ellipticines has been accomplished by utilising the one-pot formation of o-diacylarenes as a key intermediate through rearrangement of o-hydroxy ketoneExpand
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Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
The design, synthesis, and structure-activity relationships (SAR) of a series of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1) areExpand
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Enantiospecific Synthesis of Pacifigorgianes
Enantiospecific synthesis of the sesquiterpenes pacifigorgianes has been described. (R)-Carvone has been employed as the chiral starting material and an entropy assisted ring-closing metathesisExpand
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Biomimetic total syntheses of flinderoles B and C.
A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first totalExpand
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Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
The total syntheses of the thiopeptide antibiotics GE2270A (7), GE2270T (8), and GE2270C1 (9) are described. The original synthetic strategies employed utilized the hetero-Diels-Alder reaction toExpand
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Chemical synthesis and biological evaluation of palmerolide A analogues.
Molecular design and chemical synthesis of several palmerolide A analogues allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From severalExpand
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Total synthesis of antibiotics GE2270A and GE2270T.
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Cu(OTf)2 catalysed [6+2] cycloaddition reaction for the synthesis of highly substituted pyrrolo[1,2-a]indoles: rapid construction of the yuremamine core.
Lewis acid catalysed [6+2] cycloaddition reaction for the synthesis of pyrrolo[1,2-a]indoles generating three contiguous stereocenters in a highly regio- and diastereoselective manner has beenExpand
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FeCl3 catalyzed Prins-type cyclization for the synthesis of highly substituted indenes: application to the total synthesis of (±)-jungianol and epi-jungianol.
A novel approach was developed for the synthesis of highly substituted indene derivatives, using an FeCl(3) catalyzed Prins-type cyclization reaction which was further applied in the total synthesisExpand
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Biomimetic total syntheses of borreverine and flinderole alkaloids.
Dimeric indole alkaloids represent a structurally unique class of natural products having interesting biological activities. Recently, we reported the first total synthesis of flinderoles B and C,Expand
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