Daryush D. Mehta

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We report on investigations, conducted at the 2006 JHU Summer Workshop, of the use of articulatory features in automatic speech recognition. We explore the use of articulatory features for both observation and pronunciation modeling, and for both audio-only and audio-visual speech recognition. In the area of observation modeling, we use the outputs of a set(More)
In Major Depressive Disorder (MDD), neurophysiologic changes can alter motor control [1, 2] and therefore alter speech production by influencing the characteristics of the vocal source, tract, and prosodics. Clinically, many of these characteristics are associated with psychomotor retardation, where a patient shows sluggishness and motor disorder in vocal(More)
In individuals with major depressive disorder, neurophysiological changes often alter motor control and thus affect the mechanisms controlling speech production and facial expression. These changes are typically associated with psychomotor retardation, a condition marked by slowed neuromotor output that is behaviorally manifested as altered coordination and(More)
Vocal fold vibratory asymmetry is often associated with inefficient sound production through its impact on source spectral tilt. This association is investigated in both a computational voice production model and a group of 47 human subjects. The model provides indirect control over the degree of left-right phase asymmetry within a nonlinear source-filter(More)
PURPOSE In prior work, a manually derived measure of vocal fold vibratory phase asymmetry correlated to varying degrees with visual judgments made from laryngeal high-speed videoendoscopy (HSV) recordings. This investigation extended this work by establishing an automated HSV-based framework to quantify 3 categories of vocal fold vibratory asymmetry. (More)
OBJECTIVES Although near-normal conversational voices can be achieved with the phonosurgical management of early glottic cancer, there are still acoustic and aerodynamic deficits in vocal function that must be better understood to help further optimize phonosurgical interventions. Stroboscopic assessment is inadequate for this purpose. METHODS A newly(More)
PURPOSE To determine what research evidence exists to support the use of voice measures in the clinical assessment of patients with voice disorders. METHOD The American Speech-Language-Hearing Association (ASHA) National Center for Evidence-Based Practice in Communication Disorders staff searched 29 databases for peer-reviewed English-language articles(More)
Background:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53+ metastatic solid tumours.Methods:A total of 15 patients were administered p28 i.v. as a short infusion three times per week(More)
PURPOSE OF REVIEW To summarize recent technological advancements and insight into the role of stroboscopy in laryngeal imaging. RECENT FINDINGS Although stroboscopic technology has not undergone major technological improvements, recent clarifications have been made to the application of stroboscopic principles to video-based laryngeal imaging. Also recent(More)
Vocal tract resonance characteristics in acoustic speech signals are classically tracked using frameby-frame point estimates of formant frequencies followed by candidate selection and smoothing using dynamic programming methods that minimize ad hoc cost functions. The goal of the current work is to provide both point estimates and associated uncertainties(More)