Learn More
BACKGROUND Management of early-stage breast cancer in young women with mutations in BRCA1 or BRCA2 remains controversial. This study assessed the long-term risks of ipsilateral and contralateral breast cancer in a cohort of young women who underwent breast-conserving surgery followed by radiotherapy. METHODS Between 1975 and 1998, 290 women with breast(More)
The present study analyzed the association between two major processes that occur during atherogenesis: macrophage activation and peroxidation of the cellular lipids. Macrophage activation was achieved by cell incubation with phorbol myristate acetate (PMA) for 24 h at 37 degrees C, and was determined as: a) PMA concentration-dependent increment in the(More)
STUDY OBJECTIVES To characterize and compare premenstrual symptoms (mood, physical) throughout two menstrual cycles with and without estradiol administration, in women with premenstrual asthma (PMA), and to examine relationships between asthma symptoms versus premenstrual symptoms and pulmonary function versus premenstrual symptoms in these women. DESIGN(More)
Germfree rats were used in 3 experiments to study the effects of the microbial flora on survival time after acute uremia produced by a one-stage bilateral nephrectomy. Germfree rats, limited-flora rats, and conventionalized rats (all maintained continuously in isolators) were subjected to nephrectomy or to sham nephrectomy, deprived of food and water until(More)