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A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation
TLDR
A multiscale model verified by quantitative microscopy is developed and found the longest cell—cell communication distance in wild-type cells, suggesting that criticality provides an adaptive advantage and optimally sized aggregates for the dispersal of spores. Expand
A Critical-like Collective State Leads to Long-range Cell Communication in Dictyostelium discoideum Aggregation
TLDR
A multiscale model of social amoeba is developed, spanning behavior from individuals to thousands of cells, and it is shown that local cell-cell coupling via secreted chemicals may be tuned to a critical value, resulting in emergent long-range communication and heightened sensitivity. Expand