Darshana de Silva

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Seasonal and clinical aspects of rotavirus-associated diarrhoea in 98 of the 326 children hospitalised for diarrhoea are described. Rotavirus infection was detected (30% overall) throughout the year from May 1980 to April 1981, but the prevalence was higher during the rainy season (40-50%). The age group in which rotavirus was detected most frequently was(More)
BACKGROUND Hyperhomocysteinemia has been identified as a risk factor for coronary artery disease (CAD). South Asians appear to have a high incidence of CAD, while East Asians have a very low incidence. HYPOTHESIS The present study was undertaken because the relative association of plasma homocysteine levels (PH) with CAD in South Asians (SA = Indian,(More)
OBJECTIVE To establish efficacy and safety of deferiprone. DESIGN Prospective study. SETTING The Lady Ridgeway Hospital for Children, Colombo. PATIENTS Transfusion-dependent children in the age group 1 to 15 years. INTERVENTION Patients were given 75 mg/kg/day of deferiprone orally in divided doses. MEASUREMENTS Efficacy of deferiprone therapy was(More)
OBJECTIVES To determine knowledge about four genetic disorders (Down's syndrome (DS), haemophilia (haem), spinal muscular atrophy type 1 (SMA1) and Huntington's disease (HD)), attitudes towards counselling, acceptability of prenatal diagnosis and termination of pregnancies affected with these conditions. DESIGN Questionnaire survey of a cohort of medical(More)
OBJECTIVE To determine the efficacy and safety of deferiprone. DESIGN Prospective study. SETTING 5 paediatric medical units at the Lady Ridgeway Hospital for Children (LRHC), Colombo. PATIENTS Transfusion-dependent iron overloaded children in the age group 2 to 15 years. INTERVENTION Patients were given a total daily dose of 75 mg/kg of deferiprone(More)
Low birth weight is a key public health problem in many developing countries, including Sri Lanka. Indoor air pollution from tobacco smoke and kitchen-fuel smoke are among the major contributors to low birth weight, factors of which there are little awareness of in Sri Lanka. We evaluated the effect of passive smoking and kitchen-fuel smoke exposure on(More)