Darshan S. Kelley

Learn More
BACKGROUND The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied. OBJECTIVE We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in(More)
BACKGROUND Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown. OBJECTIVE A study was conducted in men to determine the effect of long-term high copper intake on indexes of copper status, oxidant damage, and immune function. (More)
Obesity is a strong risk factor for the development of CVD, hypertension and type 2 diabetes. The overall goal of the present pilot study was to feed strawberries, in the form of freeze-dried powder, to obese subjects to determine whether dietary strawberries beneficially altered lipid profiles and reduced blood markers of inflammation compared with a(More)
The basal level and hormone-affectedaminoacidtrans port of rat hepatocytesand rat hepatomacell lines H4-bI E-C3 (H35), HTC, McA-RH8994 (8994), and McA-RH7777 (7777) in culture were examined by investigating the amount of a-[1-14C]-aminoisobutyric acid (AIB) trans ported in 4 mm and up to 4 hr at 37°. The substances testedwere(More)
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated(More)
An increase in the proportion of fatty acids with higher numbers of double bonds is believed to increase lipid peroxidation, which augments the risk for many chronic diseases. (n-3) Polyunsaturated fatty acids provide various health benefits, but there is a concern that they might increase lipid peroxidation. We examined the effects of docosahexaenoic acid(More)
  • 1