Darryl L Hadsell

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The genome sequence of taurine cattle: a window to ruminant biology and evolution.

Christine G. Elsik, Ross L Tellam, +303 authors F Zhao
Science
2009

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345… (More)

GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.

Xinfu Guan, Heidi E Karpen, +9 authors Douglas Burrin
Gastroenterology
2006

BACKGROUND & AIMS Glucagon-like peptide-2 (GLP-2) is a nutrient-responsive hormone that exerts diverse actions in the gastrointestinal tract, including enhancing epithelial cell survival and… (More)

Regulation of milk protein gene expression.

Jeffrey M. Rosen, Shannon L. Wyszomierski, Darryl L Hadsell
Annual review of nutrition
1999

Studies using both transgenic mice and transfected mammary epithelial cells have established that composite response elements containing multiple binding sites for several transcription factors… (More)

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

Robert K. Dearth, Xiaojiang Cui, Hyun-jung Kim, Darryl L Hadsell, Adrian V. Lee
Cell cycle
2007

Insulin receptor substrates (IRSs) are adaptor proteins that link signaling from upstream activators to multiple downstream effectors to modulate normal growth, metabolism, survival, and… (More)

Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome.

Patricia D. Maningat, Partha Sen, +4 authors Morey W Haymond
Physiological genomics
2009

The molecular physiology underlying human milk production is largely unknown because of limitations in obtaining tissue samples. Determining gene expression in normal lactating women would be a… (More)

Effects of dietary insulin-like growth factor I on growth and insulin-like growth factor receptors in neonatal calf intestine.

Craig R. Baumrucker, Darryl L Hadsell, Jürg W. Blum
Journal of animal science
1994

Colostrum is rich in IGF-I and IGF-II, and the dietary effects of recombinant human (rh)IGF-I on the newborn are of interest. The objective of this study was to examine the effects of dietary rhIGF-I… (More)

Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows.

JoséA. Vega, Cheryl A. Gibson, T C Skaar, Darryl L Hadsell, Craig R. Baumrucker
Journal of animal science
1991

Concentrations of IGF-I and IGF-II, and IGF binding proteins (IGFBP) in serum and mammary gland secretions were surveyed during the dry period and early lactation of 30 Holstein cows. Although there… (More)

Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans.

Mahmoud Mohammad, Darryl L Hadsell, Morey W Haymond
American journal of physiology. Endocrinology and…
2012

Lactose synthesis is believed to be rate limiting for milk production. However, understanding the molecular events controlling lactose synthesis in humans is still rudimentary. We have utilized our… (More)

Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging

Darryl L Hadsell, Daniel T Torres, Jonathan R George, Anthony V. Capuco, Steven E. Ellis, Marta L Fiorotto
Experimental Gerontology
2006

Milk synthesis by the mammary gland declines during prolonged lactation despite the continued suckling stimulus and complete removal of mammary secretions. Although this process has been hypothesized… (More)

Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.

Robert K. Dearth, Xiaojiang Cui, +9 authors Adrian V. Lee
Molecular and cellular biology
2006

Insulin receptor substrates (IRSs) are signaling adaptors that play a major role in the metabolic and mitogenic actions of insulin and insulin-like growth factors. Reports have recently noted… (More)

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