Darron Steggles

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The synthesis of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines is described. The antidopaminergic and anticholinergic activities of the compounds have been examined by the respective in vitro [3H]spiperone and [3H]QNB receptor binding assay. The neuroleptic potential has been further evaluated in terms of their(More)
Use of reagent strips to monitor blood glucose concentrations in diabetic patients, with or without a glucose meter, is gaining in popularity. Favourable performance of the recently introduced Boehringer BM Test Glycemie 20-800 strips has been reported.'-4 We compared Boehringer strips and Dextrostix (Ames) with laboratory measurement of blood glucose.(More)
The synthesis of 10-piperazinyl-4H-thieno[3,2-b][1,5]benzodiazepines is described. The activity of these compounds has been assessed on the basis of their ability to produce hypothermia in mice and block a conditioned avoidance response (CAR) and produce catalepsy in rats, and the results are compared with various classical and nonclassical neuroleptic(More)
This study assessed the performance of a new most probable number test (Pseudalert®/Quanti-Tray®) for the enumeration of Pseudomonas aeruginosa from swimming pool and spa pool waters by comparing it to the international and national membrane filtration-based culture methods for P. aeruginosa: ISO 16266:2006 and UK The Microbiology of Drinking Water—Part 8(More)
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