Darren R. Lebl

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BACKGROUND We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) cells) into murine hearts of both(More)
BACKGROUND CONTEXT Traumatic fractures of the spine are most common at the thoracolumbar junction and can be a source of great disability. PURPOSE To review the most current information regarding the pathophysiology, injury pattern, treatment options, and outcomes. STUDY DESIGN Literature review. METHODS Relevant articles, textbook chapters, and(More)
BACKGROUND Implantation of bioartificial patches distorts myocardial geometry, and functional improvement of the recipient heart is usually attributed to reactive angiogenesis around the graft. With the liquid bioartificial tissue compound used in this study, we achieved targeted large-scale support of the infarcted left ventricular wall and improvement of(More)
Age-related changes in the spinal column result in a degenerative cascade known as spondylosis. Genetic, environmental, and occupational influences may play a role. These spondylotic changes may result in direct compressive and ischemic dysfunction of the spinal cord known as cervical spondylotic myelopathy (CSM). Both static and dynamic factors contribute(More)
OBJECTIVES Most tissue-engineering approaches to restore injured heart muscle result in distortion of left ventricular geometry. In the present study we suggest seeding embryonic stem cells in a liquid matrix for myocardial restoration. METHODS Undifferentiated green fluorescent protein-labeled mouse embryonic stem cells (2 x 10 6 ) were seeded in(More)
BACKGROUND CONTEXT Lateral lumbar interbody fusion (LLIF) has become an increasingly common minimally invasive procedure for selective degenerative deformity correction, reduction of low-grade spondylolisthesis, and indirect foraminal decompression. Concerns remain about the safety of the transpsoas approach to the spine due to proximity of the lumbosacral(More)
OBJECTIVE A major limitation of stem cell transfer is early donor-cell death. Here, we seek to enhance myocardial repair following injury through transplantation of cardiomyocyte-enriched human embryonic stem cells (hESC) and recipient treatment with cytoprotective (allopurinol+uricase) and anti-inflammatory (ibuprofen) agents. METHODS We injected 10(6)(More)
STUDY DESIGN Retrospective case series. OBJECTIVE To report on the rare finding of motor deficits contralateral to the transpsoas approach in patients who underwent lateral lumbar interbody fusion (LLIF). SUMMARY OF BACKGROUND DATA Although sensorimotor deficits occurring ipsilaterally to a transpsoas approach have more fully been elucidated, there(More)
Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine, but novel treatment strategies involving stem cells, growth factors, and gene therapy have the(More)
STUDY DESIGN Retrospective case series. OBJECTIVE To determine the clinical and radiographic outcomes of patients undergoing minimally invasive lateral lumbar interbody fusion (LLIF) with a minimum 2-year follow-up. SUMMARY OF BACKGROUND DATA Minimally invasive LLIF is performed through a lateral, retroperitoneal, transpsoas approach. This procedure is(More)