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BACKGROUND CONTEXT Traumatic fractures of the spine are most common at the thoracolumbar junction and can be a source of great disability. PURPOSE To review the most current information regarding the pathophysiology, injury pattern, treatment options, and outcomes. STUDY DESIGN Literature review. METHODS Relevant articles, textbook chapters, and(More)
BACKGROUND CONTEXT Lateral lumbar interbody fusion (LLIF) has become an increasingly common minimally invasive procedure for selective degenerative deformity correction, reduction of low-grade spondylolisthesis, and indirect foraminal decompression. Concerns remain about the safety of the transpsoas approach to the spine due to proximity of the lumbosacral(More)
BACKGROUND CONTEXT Despite common use of intraoperative electrophysiologic neuromonitoring, injuries to the lumbar plexus during lateral lumbar interbody fusion (LLIF) have been reported. Emerging data suggest that recombinant human bone morphogenetic protein-2 (rhBMP-2) use during an anterior or transforaminal lumbar interbody fusion may be associated with(More)
STUDY DESIGN Retrospective case series. OBJECTIVE To report on the rare finding of motor deficits contralateral to the transpsoas approach in patients who underwent lateral lumbar interbody fusion (LLIF). SUMMARY OF BACKGROUND DATA Although sensorimotor deficits occurring ipsilaterally to a transpsoas approach have more fully been elucidated, there(More)
STUDY DESIGN Retrospective case series. OBJECTIVE To determine the clinical and radiographic outcomes of patients undergoing minimally invasive lateral lumbar interbody fusion (LLIF) with a minimum 2-year follow-up. SUMMARY OF BACKGROUND DATA Minimally invasive LLIF is performed through a lateral, retroperitoneal, transpsoas approach. This procedure is(More)
STUDY DESIGN Retrospective analysis of prospective registry data. OBJECTIVE To determine the patient characteristics, risk factors, and fracture patterns associated with vertebral artery injury (VAI) in patients with blunt cervical spine injury. SUMMARY OF BACKGROUND DATA VAI associated with cervical spine trauma has the potential for catastrophical(More)
BACKGROUND Cervical spondylotic myelopathy (CSM) is a common indication for cervical spine surgery. Surgical options include anterior, posterior, or combined procedures each with specific advantages and disadvantages. QUESTIONS/PURPOSES This article will provide a description of the various anterior alternatives and discuss the available evidence used in(More)
OBJECTIVES Most tissue-engineering approaches to restore injured heart muscle result in distortion of left ventricular geometry. In the present study we suggest seeding embryonic stem cells in a liquid matrix for myocardial restoration. METHODS Undifferentiated green fluorescent protein-labeled mouse embryonic stem cells (2 x 10 6 ) were seeded in(More)
BACKGROUND We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) cells) into murine hearts of both(More)
BACKGROUND Implantation of bioartificial patches distorts myocardial geometry, and functional improvement of the recipient heart is usually attributed to reactive angiogenesis around the graft. With the liquid bioartificial tissue compound used in this study, we achieved targeted large-scale support of the infarcted left ventricular wall and improvement of(More)